Title:
心肺バイパス(CPB)手術の術後合併症を低減するための組成物
Document Type and Number:
Japanese Patent JP4819226
Kind Code:
B2
Abstract:
The invention provides a method of reducing postoperative complications of cardiopulmonary bypass (CPB) surgery in which an effective amount of a methylol transfer agent, such as taurolidine, is administered to a patient in conjunction with CPB surgery. Patients undergoing crystalloid cardioplegia who were treated with taurolidine showed reduced levels of IL-6 and increased levels of IL-10 when compared to crystalloid patients administered a placebo.
Inventors:
H. Paul Redmond
Rolf ve pufilman
Rolf ve pufilman
Application Number:
JP2001000740A
Publication Date:
November 24, 2011
Filing Date:
January 05, 2001
Export Citation:
Assignee:
Ed. Geistlich Soehne AG fuer chemische Industrie
International Classes:
A61K31/549; C07D285/18; A61K31/00; A61K45/00; A61K45/06; A61M1/36; A61P7/00; A61P9/00; A61P9/06; A61P31/00; A61P31/04; A61P41/00; A61P43/00
Domestic Patent References:
| JP55151513A | ||||
| JP60105618A | ||||
| JP10146350A | ||||
| JP9509074A |
Foreign References:
| WO1998051223A1 | ||||
| WO1999010009A1 |
Other References:
Langenbecks Arch Chir ,1997年,Vol.382 [Suppl 1],pp.S26-S30
"Taurolidin as a local disinfectant in open heart surgery",Israel Journal of Medical Sciences,1996年,Vol.32 No.10,p.1020
"Taurolidin as a local disinfectant in open heart surgery",Israel Journal of Medical Sciences,1996年,Vol.32 No.10,p.1020
Attorney, Agent or Firm:
Michiharu Soga
Kajinami order
Kazuhiro Oyaku
Kajinami order
Kazuhiro Oyaku