Title:
チオアミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤
Document Type and Number:
Japanese Patent JP4829506
Kind Code:
B2
Abstract:
To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions. A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof:
wherein A is N, NO, C-NO 2 or C-CN; Hal is a halogen; M 1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO 2 ; M 2 is amino, O, S or a single bond; R 1 is a halogen, alkyl or the like; each of R 2 , R 3 , R 4 and R 5 is independently H, alkyl or the like; R 6 is a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.
Inventors:
Kato Grammar
Kimura Hirohiko
Kiyoshi Tamai
Kazuhiro Yamamoto
Mitsuo Sano
Mori Shinya
Takashi Okada
Ueki Toshihiko
Kumiko Higashi
Kimura Hirohiko
Kiyoshi Tamai
Kazuhiro Yamamoto
Mitsuo Sano
Mori Shinya
Takashi Okada
Ueki Toshihiko
Kumiko Higashi
Application Number:
JP2005028855A
Publication Date:
December 07, 2011
Filing Date:
February 04, 2005
Export Citation:
Assignee:
Ishihara Sangyo Co., Ltd.
International Classes:
C07D213/64; C07D237/20; A61K31/18; A61K31/352; A61K31/401; A61K31/404; A61K31/4045; A61K31/41; A61K31/415; A61K31/4192; A61K31/423; A61K31/425; A61K31/426; A61K31/428; A61K31/437; A61K31/44; A61K31/4409; A61K31/4439; A61K31/444; A61K31/4545; A61K31/455; A61K31/47; A61K31/4965; A61K31/50; A61K31/505; A61K31/517; A61K31/5377; A61K31/538; A61K31/541; A61P3/10; A61P5/14; A61P11/02; A61P11/06; A61P17/00; A61P17/04; A61P19/02; A61P21/04; A61P25/00; A61P27/14; A61P27/16; A61P29/00; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07C233/66; C07C233/69; C07C233/71; C07C233/78; C07C311/17; C07C323/42; C07C327/48; C07D207/09; C07D209/04; C07D209/08; C07D209/42; C07D213/69; C07D213/70; C07D213/74; C07D213/81; C07D213/82; C07D213/83; C07D215/20; C07D215/22; C07D231/18; C07D231/20; C07D235/08; C07D237/04; C07D239/30; C07D239/34; C07D239/42; C07D239/60; C07D241/12; C07D241/18; C07D249/18; C07D257/04; C07D263/58; C07D277/20; C07D277/36; C07D277/74; C07D311/08; C07D311/46; C07D401/12; C07D471/04
Domestic Patent References:
| JP2003506466A | ||||
| JP2002503723A | ||||
| JP9176100A | ||||
| JP52100476A | ||||
| JP2003306433A | ||||
| JP2002338537A | ||||
| JP2002284783A |
Foreign References:
| US3374084 |
Other References:
日本化学雑誌,1969年,90(10),p.1051-1053
Bulletin de la Societe Chimique de France,1949年,p.172-177
Bulletin de la Societe Chimique de France,1949年,p.172-177