Title:
アテローム性動脈硬化症の治療におけるキレート化剤の使用
Document Type and Number:
Japanese Patent JP4831383
Kind Code:
B2
Abstract:
The invention provides the use of dipyridoxyl or aminopolycarboxylic acid based chelating agents, metal chelates and salts thereof, in the manufacture of a therapeutic agent for use in the treatment or prophylaxis of atherosclerosis and related conditions in the human or non-human animal body. Preferred compounds for use in the method of the invention are compounds of formula (I) or a metal chelate or salt thereof (wherein in formula (I) each R1 independently represents hydrogen or -CH2COR5; R5 represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamido; each R2 independently represents a group XYR6; X represents a bond, or a C1-3 alkylene or oxoalkylene group optionally substituted by a group R7; Y represents a bond, an oxygen atom or a group NR6; R6 is a hydrogen atom, a group COOR8, an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more groups selected from COOR8, CONR82, NR82, OR8, =R8, =O, OP(O)(OR8)R7 and OSO3M; R7 is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group; R8 is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group; M is a hydrogen atom or one equivalent of a physiologically tolerable cation, e.g. an alkali or alkaline earth cation, an ammonium ion or an organic amine cation, such as a meglumine ion; R3 represents a C1-8 alkylene group, preferably a C1-6, e.g. a C2-4 alkylene group, a 1,2-cycloalkylene group, or a 1,2-arylene group; each R4 independently represents hydrogen or C1-3 alkyl; and each R9 independently may be absent or represents hydrogen, alkyl, hydroxyalkyl or carboxyalkyl).
Inventors:
Jan Ulof Gustav Carlson
Rolf Yelan Gustav Unders
Anders Olson
Boo Seeden
Pell Inge
Tudor griffith
Derek Grant
Robertson Tworte
Helge Refsum
Rolf Yelan Gustav Unders
Anders Olson
Boo Seeden
Pell Inge
Tudor griffith
Derek Grant
Robertson Tworte
Helge Refsum
Application Number:
JP2000526265A
Publication Date:
December 07, 2011
Filing Date:
December 18, 1998
Export Citation:
Assignee:
GE Healthcare Aksuye Sersukapu
International Classes:
A61K31/444; A61K31/198; A61K31/44; A61K31/675; A61P9/10
Domestic Patent References:
| JP2290819A | ||||
| JP2180818A | ||||
| JP63287791A | ||||
| JP63280088A | ||||
| JP2504269A | ||||
| JP62056426A | ||||
| JP7507288A | ||||
| JP2000513351A |
Foreign References:
| US3838196 |
Other References:
E. OLSZEWER, J.P. CARTER,EDTA CHELATION THERAPY IN CHRONIC DEGENERATIVE DISEASE,MEDICAL HYPOTHESES,1988年 9月 1日,V27N1,P41-49
EDTA CHELATION THERAPY FOR ARTERIOSCLEROTIC HEART DISEASE,MED.LETT.DRUGS THER.,1981年 1月 1日,V23N1,P51
D S Leake et al.,The oxidative modification of low-density lipoproteins by macrophages.,Biochemical Journal,1990年 9月15日,Vol. 270, No. 3,pp. 741-748
Yasukazu Yoshida et al.,Effects of metal chelating agents on the oxidation of lipids induced by copper and iron,Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism,1993年12月 2日,Vol. 1210, No. 1,pp. 81-88
EDTA CHELATION THERAPY FOR ARTERIOSCLEROTIC HEART DISEASE,MED.LETT.DRUGS THER.,1981年 1月 1日,V23N1,P51
D S Leake et al.,The oxidative modification of low-density lipoproteins by macrophages.,Biochemical Journal,1990年 9月15日,Vol. 270, No. 3,pp. 741-748
Yasukazu Yoshida et al.,Effects of metal chelating agents on the oxidation of lipids induced by copper and iron,Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism,1993年12月 2日,Vol. 1210, No. 1,pp. 81-88
Attorney, Agent or Firm:
Arakawa Satoshi
Hirokazu Ogura
Toshihisa Kurokawa
Hirokazu Ogura
Toshihisa Kurokawa