Title:
eNOS発現に起因する疾患の予防または治療薬
Document Type and Number:
Japanese Patent JP4836388
Kind Code:
B2
Abstract:
The present invention provides a safe therapeutic agent with negligible adverse effects, which activates eNOS so that it optimally functions, and thereby treats or prevents diseases or pathological conditions caused by a condition where the expression product of eNOS gene does not exhibit its proper function. More specifically, the present invention relates to an agent for treating or preventing diseases or pathological conditions caused by an increase in eNOS, which contains, as an active ingredient, a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein each of R<1> and R<2> represents a hydrogen atom, or R<1> and R<2> together form a single bond, and when each of R<1> and R<2> represents a hydrogen atom, R<3> represents -CH(OH)CH(OH)CH3, -CH(OCOCH3)CH(OCOCH3)CH3, -CH3, -CH2OH or a phenyl group, and when R<1> and R<2> together form a single bond, R<3> represents -COCH(OH)CH3.
Inventors:
Kawashima Shigenosuke
Mitsuhiro Yokoyama
Mitsuhiro Yokoyama
Application Number:
JP2002082159A
Publication Date:
December 14, 2011
Filing Date:
March 22, 2002
Export Citation:
Assignee:
Daiichi Sankyo Co., Ltd.
International Classes:
A61K31/519; A61K31/525; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P39/06; A61P43/00; C07D475/04; C07D487/04
Domestic Patent References:
| JP10338637A |
Other References:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,1997,Vol.237,p.340-344
川村光信,LDL易酸化性の指標とその検出法,高脂血症,2001年,p.575
Biochemical and Biophysical Reserch Communications,1999,Vol.263,p.681-684
川村光信,LDL易酸化性の指標とその検出法,高脂血症,2001年,p.575
Biochemical and Biophysical Reserch Communications,1999,Vol.263,p.681-684
Attorney, Agent or Firm:
Shinjiro Ono
Kimiki Ishibashi
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Osamu Yamamoto
Kimiki Ishibashi
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Osamu Yamamoto