Title:
尿管結石症の治療用医薬
Document Type and Number:
Japanese Patent JP4865724
Kind Code:
B2
Abstract:
The present invention provides pharmaceutical compositions useful for relieving pain caused by ureteral calculi, facilitating exclusion of ureteral calculi or the like. That is, the present invention provides a pharmaceutical composition for the treatment of ureteral lithiasis, which comprises as an active ingredient an indoline derivative represented by the following general formula (I) or a salt thereof. In the formula, R represents saturated or unsaturated aliphatic acyl which may have a substituent; hydroxyalkyl; aliphatic acyloxyalkyl; lower alkyl which has as a substituent lower alkoxy, carboxy, lower alkoxycarbonyl, aryl-substituted lower alkoxycarbonyl, carbamoyl, mono or di(lower alkyl)-substituted carbamoyl or cyano; optionally substituted aromatic acyl; furoyl or pyridylcarbonyl; R 1 represents cyano or carbamoyl; and R 2 represents lower alkyl which may have as a substituent halogen, cyano or aryl.
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Inventors:
Kobayashi Mamoru
Aitaka Toyama
Kumi Kobayashi
Aitaka Toyama
Kumi Kobayashi
Application Number:
JP2007546458A
Publication Date:
February 01, 2012
Filing Date:
November 22, 2006
Export Citation:
Assignee:
Kissei Pharmaceutical Co., Ltd.
International Classes:
A61K31/404; A61P13/04; C07D209/08
Domestic Patent References:
| JPH08501538A | 1996-02-20 |
Attorney, Agent or Firm:
Nobuko Yanagi