Title:
ポリペプチド産生細胞
Document Type and Number:
Japanese Patent JP4870208
Kind Code:
B2
Abstract:
The current invention describes a nucleic acid comprising in a 5' to 3' direction a) a first nucleic acid encoding a heterologous polypeptide without an in frame stop codon, b) a second nucleic acid beginning with a 5' splice donor site and terminated by a 3' splice acceptor site comprising an in frame translational stop codon and a polyadenylation signal, and c) a nucleic acid encoding i) at least a fragment of a transmembrane domain, or ii) a signal peptide for a GPI-anchor.
Inventors:
Endor Joseph
Kopetsky Air Hard
Proettner Oliver
Schwarz Ursula
Tiefensaler george
Kopetsky Air Hard
Proettner Oliver
Schwarz Ursula
Tiefensaler george
Application Number:
JP2009510343A
Publication Date:
February 08, 2012
Filing Date:
May 15, 2007
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C12N15/09; C12N1/15; C12N1/19; C12N5/10; C12P21/02; C12P21/08
Foreign References:
| WO2005089285A2 | 2005-09-29 | |||
| WO2001092291A2 | 2001-12-06 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki