Title:
発酵による精密化学物質の製造方法
Document Type and Number:
Japanese Patent JP4903742
Kind Code:
B2
Abstract:
The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
Inventors:
Zelder, oscar
Croplogge, Corinna
Schrader, Hartwig
Haefner, stephan
Craiger, Burghard
Kiefer, Patrick
Heinzul, Elmer
Wittmann, Christoph
Croplogge, Corinna
Schrader, Hartwig
Haefner, stephan
Craiger, Burghard
Kiefer, Patrick
Heinzul, Elmer
Wittmann, Christoph
Application Number:
JP2008095922A
Publication Date:
March 28, 2012
Filing Date:
April 02, 2008
Export Citation:
Assignee:
BASF SE
International Classes:
C12N9/16; C12N15/09; C12P13/08; C12R1/15
Domestic Patent References:
| JP2002191370A |
Foreign References:
| WO2001000844A1 |
Other References:
Advances in Biochemical Engineering,2003年,vol.79,pp.59-112
Appl Microbiol Biotechnol,2002年,vol.58,pp.217-223
APPLIED AND ENVIRONMENTAL MICROBIOLOGY,2004年,vol.70 no.1,pp.229-239
Journal of Industrial Microbiology and Biotechnology,2002年,vol.28,pp.338-343
Eur. J. Biochem.,1998年,vol.254,pp.96-102
Journal of Biotechnology,2003年 9月,vol.104,pp.185-197
Biol. Chem.,2000年,vol.381,pp.899-910
APPLIED AND ENVIRONMENTAL MICROBIOLOGY,2002年,vol.68 no.12,pp.5843-5859
Appl Microbiol Biotechnol,2002年,vol.58,pp.217-223
APPLIED AND ENVIRONMENTAL MICROBIOLOGY,2004年,vol.70 no.1,pp.229-239
Journal of Industrial Microbiology and Biotechnology,2002年,vol.28,pp.338-343
Eur. J. Biochem.,1998年,vol.254,pp.96-102
Journal of Biotechnology,2003年 9月,vol.104,pp.185-197
Biol. Chem.,2000年,vol.381,pp.899-910
APPLIED AND ENVIRONMENTAL MICROBIOLOGY,2002年,vol.68 no.12,pp.5843-5859
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka