Title:
セファロタキシンアルカロイド組成物およびその使用
Document Type and Number:
Japanese Patent JP4929436
Kind Code:
B2
Abstract:
A method of treatment of a host with a cellular proliferative disease, comprising contacting the host with a cephalotaxine and an antiproliferative agent, each in an amount sufficient to modulate said cellular proliferative disease, is described. In some embodiments, the cephalotaxine comprises homoharringtonine (cephalotaxine, 4-methyl-2-hydroxy-2-(4-hydroxy-4-methyl pentyl)butanediocate ester). Antiproliferative agents of the invention comprise alkylating agents, intercalating agents, metal coordination complexes, pyrimidine nucleosides, purine nucleosides, inhibitors of nucleic acid associated enzymes and proteins, and agents affecting structural proteins and cytoplasmic enzymes.
Inventors:
Dennis M. Brown
Application Number:
JP2001566662A
Publication Date:
May 09, 2012
Filing Date:
March 15, 2001
Export Citation:
Assignee:
CHEMGENEX Pharmaceuticals, Inc.
International Classes:
A61K31/55; A61K45/00; A61K31/352; A61K31/36; A61K31/473; A61K31/4745; A61K31/475; A61K31/513; A61K31/70; A61K31/7042; A61K31/7048; A61K31/7068; A61K31/7076; A61K33/243; A61K45/06; A61P35/00
Other References:
C. VISANI,LEUKEMIA,スウェーデン,1997年,V11,P624-628
Proceedings of the American Association for Cancer Research,1982年,Vol.23,p.199
ZHANG,ASIA PACIFIC JOURNAL OF PHARMACOLOGY,SG,SINGAPORE UNIVERSITY PRESS,1992年,V7,P191-195
Proceedings of the American Association for Cancer Research,1982年,Vol.23,p.199
ZHANG,ASIA PACIFIC JOURNAL OF PHARMACOLOGY,SG,SINGAPORE UNIVERSITY PRESS,1992年,V7,P191-195
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Takuya Kikuchi
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Takuya Kikuchi