Title:
ステロイドスルファターゼのインヒビターとしてのエストロゲン-17-スルファメート
Document Type and Number:
Japanese Patent JP4958377
Kind Code:
B2
Abstract:
There is provided a compound of Formula I
wherein X is a ring system; R 1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R 2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein when X is a steroidal structure and both of R 1 and R 2 are sulphamate groups, the steroidal ring system (X) represents an oestrogen; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth. There is also provided a compound of Formula VIII
wherein R 2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.
Inventors:
Potter, Barry Victor Lloyd
Reed, michael john
Leblond, Bertrand
Leeds, Matthew Paul
Pro Hit, Azul
Reed, michael john
Leblond, Bertrand
Leeds, Matthew Paul
Pro Hit, Azul
Application Number:
JP2002521488A
Publication Date:
June 20, 2012
Filing Date:
August 17, 2001
Export Citation:
Assignee:
Sterix limited
International Classes:
A61K31/56; C07J41/00; A61K31/37; A61K31/565; A61K31/566; A61K31/567; A61K31/569; A61K45/00; A61P1/00; A61P1/02; A61P1/04; A61P1/14; A61P3/10; A61P5/14; A61P5/16; A61P5/30; A61P5/32; A61P7/00; A61P7/04; A61P9/00; A61P9/04; A61P9/10; A61P11/02; A61P11/06; A61P15/00; A61P15/08; A61P15/18; A61P17/00; A61P17/04; A61P17/06; A61P19/00; A61P19/02; A61P19/04; A61P19/10; A61P21/04; A61P25/00; A61P25/02; A61P25/06; A61P25/08; A61P25/28; A61P27/02; A61P27/14; A61P29/00; A61P31/00; A61P31/04; A61P31/18; A61P35/00; A61P35/04; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07J31/00
Domestic Patent References:
| JP2002542255A | ||||
| JP2003517002A | ||||
| JP2003519658A | ||||
| JP2004511441A |
Foreign References:
| WO1998042729A1 | ||||
| WO1996005216A1 | ||||
| WO1993005064A1 | ||||
| WO1999064013A1 |
Other References:
ROMER, JOHANNES,J. PRAKT. CHEM.,1999年,V341N6,P574-583
KASCH, H.,In Vitro Selection of Sulphatase Inhibitors for Tumour Diagnosis with PET and for Tumour Therapy,Wissenschaftlich-Technische Berichte,1999年,FZR-283,p. 54-57
BRUNNER H,MONATSHEFTE FUR CHEMIE,オーストリア,SPRINGER VERLAG.,1993年,V124N1,P83-102
KASCH, H.,In Vitro Selection of Sulphatase Inhibitors for Tumour Diagnosis with PET and for Tumour Therapy,Wissenschaftlich-Technische Berichte,1999年,FZR-283,p. 54-57
BRUNNER H,MONATSHEFTE FUR CHEMIE,オーストリア,SPRINGER VERLAG.,1993年,V124N1,P83-102
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita