Title:
ウレア誘導体、それを含有する医薬組成物およびそれらの医薬用途
Document Type and Number:
Japanese Patent JP5009785
Kind Code:
B2
Abstract:
Urea derivatives represented by the following general formula (I) :
which have an agonism of V2 receptor, are useful as agents for the treatment or prevention of diabetes insipidus, nocturia, nocturnal enuresis, overactive bladder or the like.
In the formula, R 1 represents a hydrogen atom or a C 1-6 alkyl group which may have a substituent, R 2 is a hydrogen atom or a C 1-6 alkyl group, R 3 is a hydrogen atom, a C 1-6 alkyl group or the like, R 4 , R 5 and R 6 are independently a hydrogen atom, a halogen atom or the like, R 7 is a hydrogen atom, a heteroaryl group which may have a substituent, a C 3-8 cycloalkyl group, an amino group which may have a substituent or a C 1-6 alkoxy group which may have a substituted group, M 1 is a single bond, a C 1-4 alkylene group or the like, Y is N or CR F (in the formula, and R F represents a hydrogen atom, a C 1-6 alkyl group or the like, or pharmaceutically acceptable salts thereof, or prodrugs thereof, or pharmaceutical compositions comprising the same and pharmaceutical uses thereof.
Inventors:
Suzuki Ritsu
Kenji Yokoyama
Kondo Ryudai
Hirasawa Hideaki
Miki Kamihara
Hiroaki Kobayashi
Kenji Yokoyama
Kondo Ryudai
Hirasawa Hideaki
Miki Kamihara
Hiroaki Kobayashi
Application Number:
JP2007510432A
Publication Date:
August 22, 2012
Filing Date:
March 23, 2006
Export Citation:
Assignee:
Kissei Pharmaceutical Co., Ltd.
International Classes:
C07D243/14; A61K31/5513; A61K45/00; A61P7/00; A61P7/04; A61P13/02; A61P25/00; A61P43/00; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/10; C07D403/12; C07D403/14; C07D413/10; C07D413/12
Domestic Patent References:
| JPH0616643A | 1994-01-25 |
Foreign References:
| WO2001049682A1 | 2001-07-12 | |||
| WO1997030992A1 | 1997-08-28 |