Title:
細胞のアポトーシスの検出および定量化用の化合物およびキット
Document Type and Number:
Japanese Patent JP5030961
Kind Code:
B2
Abstract:
3-hydroxyflavone derivatives are useful in the detection and the quantification of cell apoptosis. Such derivatives are also useful as fluorescent probes in studying lipid asymmetry of cell plasma membrane and in detecting apopoptic cells. The derivatives can be used to monitor the evolution of diseases involving cell apoptosis.
Inventors:
Mary Eve
Crimshenko Andrey
Demshenko Alexandre
Sinker Vasil
Crimshenko Andrey
Demshenko Alexandre
Sinker Vasil
Application Number:
JP2008535133A
Publication Date:
September 19, 2012
Filing Date:
October 11, 2006
Export Citation:
Assignee:
Saintur Nacional de la Rushche Shandifique
Universite Louis Pasteur (Strasbourg Premiere)
Universite Louis Pasteur (Strasbourg Premiere)
International Classes:
C07D311/30; A61B5/00; C07D409/04; C12Q1/02; G01N33/15; G01N33/48; G01N33/50
Domestic Patent References:
| JP2005523945A |
Other References:
Shynkar, V. V., et al.,"Two-color fluorescent probes for imaging the dipole potential of cell plasma membranes",Biochimica et Biophysica Acta,2005年 7月 1日,Vol.1712, No.2,pp.128-136
Shynkar, V. V., et al.,"Fluorescent Biomembrane Probe for Ratiometric Detection of Apoptosis",Journal of the American Chemical Society,2007年 1月27日,Vol.129, No.7,pp.2187-2193
Shynkar, V. V., et al.,"Fluorescent Biomembrane Probe for Ratiometric Detection of Apoptosis",Journal of the American Chemical Society,2007年 1月27日,Vol.129, No.7,pp.2187-2193
Attorney, Agent or Firm:
Norihiko Hibi
Einosuke Kishimoto
Akira Watanabe
Einosuke Kishimoto
Akira Watanabe