Title:
カルボキサミドスピロラクタムCGRP受容体拮抗薬
Document Type and Number:
Japanese Patent JP5039553
Kind Code:
B2
Abstract:
The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved
Inventors:
Williams, Teresa M
Basily, Christopher S
Tatsuker, Thomas J.A.
Stamp,craig ai
Bell, Ian Em
Basily, Christopher S
Tatsuker, Thomas J.A.
Stamp,craig ai
Bell, Ian Em
Application Number:
JP2007531340A
Publication Date:
October 03, 2012
Filing Date:
September 09, 2005
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
C07D209/54; A61K31/403; A61K31/404; A61K31/4178; A61K31/438; A61K31/4439; A61K31/444; A61K31/454; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/55; A61K31/553; A61P9/00; A61P25/06; A61P43/00; C07D401/12; C07D403/12; C07D413/12; C07D471/20; C07D519/00
Domestic Patent References:
| JP2003531905A |
Foreign References:
| WO2006031610A1 | ||||
| US4307108 | ||||
| WO2004087649A1 | ||||
| WO2004082602A1 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Katsuma Osaki
Katsuma Osaki