Title:
結晶β-ラクタム中間体
Document Type and Number:
Japanese Patent JP5047418
Kind Code:
B2
Abstract:
The novel intermediate compound crystalline 7-[2-(2-fomylaminothiazol-4-yl)-2 -(Z)-(methoxyimino)acetamido]-3-methoxymethyl-3-cephem-4-carboxylic acid-1 -(isopropoxy/crystallization of cefpodoxime proxetil. The crystallization process comprises dissolving or suspending the intermediate in the presence of a nitrile or a ketone or mixtures thereof; at a ratio of 1 gm of the intermediate to 2-15 ml nitrile; or at a ratio of 1 gm of the intermediate to 3-15 ml ketone; in the presence of 5-80 ml water; and thereafter isolating the intermediate in crystalline form and converting the intermediate by splitting off the formyl group from the amino group attached to the thiazolyl group, to obtain the desired product cefpodoxime proxetil, in the form of a diastereoisomeric mixture in a ratio of B/(A+B) of 0.5 to 0.6.
Inventors:
Grail, Yulia
Rudetshear, Johannes
Klaus Thoth Schneich
Wolf, Siegfried
Rudetshear, Johannes
Klaus Thoth Schneich
Wolf, Siegfried
Application Number:
JP2000615624A
Publication Date:
October 10, 2012
Filing Date:
May 03, 2000
Export Citation:
Assignee:
SANDOZ AKTIENGESELLSCHAFT
International Classes:
C07D501/34; C07D501/00; C07D501/02; C07D501/04; C07D501/06; C07D501/12; C07D501/18
Domestic Patent References:
| JP60004189A | ||||
| JP3911124B2 | ||||
| JP5178861A | ||||
| JP3024086A | ||||
| JP1249778A | ||||
| JP3031286A | ||||
| JP5213969A | ||||
| JP57059894A | ||||
| JP60067483A |
Other References:
T. HAMAURA et al,Gel formation of cefpodoxime proxetil,S.T.P.Pharma Sciences,1995年,Vol.5, No.4,p.324-331
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura