Title:
アリールイミダゾールおよびその抗癌剤としての使用
Document Type and Number:
Japanese Patent JP5095216
Kind Code:
B2
Abstract:
Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods of preparing the compounds and pharmaceutical compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-cancer agents; wherein: R1 is aryl, substituted aryl, heterocycle, substituted heterocycle, heteroaryl, substituted heteroaryl or amino; R2 and R3 are independently aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl or R2 and R3 when taken together along with the carbon atoms they are attached to, form aryl or substituted aryl, and R4 is hydrogen, halogen, hydroxyl, thiol, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, alkylalkenyl, alkyl alkynyl, alkoxy, alkylthio, aryl, aryloxy, amino, amido, carboxyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, heteroalkyl, cycloalkyl, substituted cycloalkyl, alkylcycloalkyl, alkylcycloheteroalkyl, nitro, cyano or —S(O)0-2R wherein R is alkyl, substituted alkyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl.
Inventors:
Husca Mario
Al-Kawasume Raed
Young Apin H
Lee Young
Rock lisa
Al-Kawasume Raed
Young Apin H
Lee Young
Rock lisa
Application Number:
JP2006539065A
Publication Date:
December 12, 2012
Filing Date:
November 15, 2004
Export Citation:
Assignee:
Laurus Therapeutics, Inc.
International Classes:
C07D233/64; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/437; A61K31/4375; A61K31/4439; A61K45/00; A61P35/00; A61P35/02; A61P43/00; C07D233/54; C07D235/02; C07D401/04; C07D401/14; C07D403/04; C07D403/14; C07D405/14; C07D409/14; C07D471/04; C07D471/14; C07D471/16; C07D495/04
Domestic Patent References:
| JP2006503817A | ||||
| JP2001506997A |
Foreign References:
| CN1289774A | ||||
| CN1289775A | ||||
| WO2003087026A1 | ||||
| WO2003032984A1 | ||||
| WO2002072576A1 | ||||
| WO2001026467A1 | ||||
| WO2002024680A1 | ||||
| WO2000059541A1 | ||||
| WO1999007701A1 | ||||
| EP0812829A1 | ||||
| WO1999002155A1 | ||||
| WO1997036587A1 | ||||
| US3279918 | ||||
| EP0165588A1 | ||||
| EP0077024A1 | ||||
| US3714181 | ||||
| EP1428831A1 |
Other References:
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Z.Naturforschg.B,1967年,vol.22,pp.132-141
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Boll.Chim.Farmaceutico,1999年,vol.138,pp.453-456
J.Org.Chem.,1975年,vol.40,pp.1641-1642
J.Indian Chem.Soc.,1979年,vol.56,pp.620-624
Indian J. Chem.B,1966年,vol.4,pp.419-420
Uchenye Zapiski,1971年,vol.81,pp.95-97
Russ.J.Org.Chem.,2002年,vol.38,pp.726-730
Chem.Het.Comp.,1971年,vol.7,pp.950-952
Russ.J.Phys.Chem.,2003年,vol.77,pp.1709-1714
J.Chem.Soc.,1923年,vol.123,pp.1559-1565
J.Am.Chem.Soc.,1943年,vol.65,pp.452-456
J.Org.Chem.,1979年,vol.44,pp.41-49
Z.Naturforschg.B,1967年,vol.22,pp.132-141
Nippon Kagaku Zasshi,1971年,vol.92,pp.365-370
Boll.Chim.Farmaceutico,1999年,vol.138,pp.453-456
J.Org.Chem.,1975年,vol.40,pp.1641-1642
Attorney, Agent or Firm:
Haruka International Patent Office