Title:
光学活性アルコールを製造するための酵素的還元
Document Type and Number:
Japanese Patent JP5102222
Kind Code:
B2
Abstract:
Preparation of optically active alkanol compound (I) comprises incubating an enzyme with a polypeptide sequence of SEQ ID NO:1 (Not defined) or the SEQ ID NO:1 with up to 25% of amino acids modified by deletion, insertion and/or substitution and at least 50% of which possess enzymatic activity, in a medium containing alkanone compound (II) and isolating the product, where (II) is enzymatically reduced to (I). Preparation of optically active alkanol compound of formula (I) comprises incubating an enzyme with a polypeptide sequence of SEQ ID NO:1 (Not defined) or the SEQ ID NO:1 with up to 25% of amino acids modified by deletion, insertion and/or substitution and at least 50% of which possess enzymatic activity, in a medium containing alkanone compound of formula Cyc-(C=O)-(CH 2) n-CH 2-R 1>(II) and isolating the product, where (II) is enzymatically reduced to (I). n : 0-5; Cyc : optionally substituted, mono- or polynuclear, (un)saturated, carbocylic or heterocyclic ring; R 1>halo, SH, OH, NO 2, NR 2>R 3> or NR 2>R 3>R 4+>X ->; R 2>-R 4>H, lower alkyl or lower alkoxy; and X ->counter ion. An independent claim is also included for the enzyme with dehydrogenase activity. [Image] ACTIVITY : Antidepressant; Uropathic. No biological data given. MECHANISM OF ACTION : None given.
Inventors:
Sturmer, Liner
Keseler, maria
Bernhard, Hauer
Friedrich, thomas
Braoor, Michael
Schrader, Hartwig
Keseler, maria
Bernhard, Hauer
Friedrich, thomas
Braoor, Michael
Schrader, Hartwig
Application Number:
JP2008546390A
Publication Date:
December 19, 2012
Filing Date:
December 13, 2006
Export Citation:
Assignee:
BASF SE
International Classes:
C12P7/02; C12N9/04; C12P17/00; C12N15/09; C12R1/01; C12R1/365; C12R1/38; C12R1/41; C12R1/465
Domestic Patent References:
| JP7503371A |
Foreign References:
| WO2005033094A1 | ||||
| WO2005108590A1 |
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita