Title:
アルツハイマーおよび関連する神経変性障害の処置のためのタウ凝集阻害剤としてのナフトキノン誘導体
Document Type and Number:
Japanese Patent JP5147157
Kind Code:
B2
Abstract:
Provided are napthoquinone-type compounds which can be used to modulate the aggregation of protein (e.g. tau) associated with neurodegenerative disease (e.g. Alzheimer's disease). Structure-function characteristics for oxidised and reduced napthoquinone-type compounds, such as menadione-related compounds, are disclosed. The invention further provides methods of treatment or prophylaxis of neurodegenerative diseases and/or clinical dementias based on the compounds.
Inventors:
Vischic, Claude Michelle
David Horsley
Rickard, Janet Elizabeth
Charles Robert, Harrington
David Horsley
Rickard, Janet Elizabeth
Charles Robert, Harrington
Application Number:
JP2003513541A
Publication Date:
February 20, 2013
Filing Date:
July 16, 2002
Export Citation:
Assignee:
WISTA LABORATORIES LTD.
International Classes:
A61K31/122; A61P1/16; A61K31/192; A61K31/222; A61K31/255; A61P3/10; A61P7/02; A61P9/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P31/00; A61P35/00; A61P43/00; C07C50/10; C07C50/14; C07C50/24; C07C50/32; C07C50/38; C07C65/11; C07C69/16; C07C255/52; C07C305/22; C07C309/25
Domestic Patent References:
| JP11335244A | ||||
| JP11502925A | ||||
| JP6505005A | ||||
| JP61143334A |
Foreign References:
| DE19504003A1 | ||||
| WO1997003940A1 | ||||
| US4560511 |
Other References:
CHEMICAL RESEARCH IN TOXICOLOGY,1998年,11(6),P.608-613
HETEROCYCLIC COMMUNICATIONS,1999年,5(4),P.343-348
PHARMACY AND PHARMACOLOGY COMMUNICATIONS,1999年,5(4),P.281-285
INDIAN JOURNAL OF PHARMACOLOGY,1999年,31(3),P.222-224
HETEROCYCLIC COMMUNICATIONS,1999年,5(4),P.343-348
PHARMACY AND PHARMACOLOGY COMMUNICATIONS,1999年,5(4),P.281-285
INDIAN JOURNAL OF PHARMACOLOGY,1999年,31(3),P.222-224
Attorney, Agent or Firm:
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Suzuki Otoya
St. Tanaka
Yuichi Okazaki
Toshio Miyake
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Suzuki Otoya
St. Tanaka
Yuichi Okazaki
Toshio Miyake