Title:
TRACP5bの製造方法
Document Type and Number:
Japanese Patent JP5177431
Kind Code:
B2
Abstract:
Silkworms which have (i) a DNA encoding a transcriptional regulator operably linked downstream of a promoter of a DNA encoding a protein specifically expressed in the silk gland and (ii) a DNA encoding TRACP5 operably linked downstream of a target promoter of the transcriptional regulator were produced. The result showed that active TRACP5b was produced from the silkworms. This means that TRACP5 produced from the silk gland of the silkworms undergoes processing in the silk gland that is similar to the processing taking place at bone resorption sites.
Inventors:
Kiyokawa Iwao
Kenya Ohashi
Toshihide Miura
Katsuhiro Katayama
Toshiki Tamura
Isao Kobayashi
Hideki Settsu
Kenya Ohashi
Toshihide Miura
Katsuhiro Katayama
Toshiki Tamura
Isao Kobayashi
Hideki Settsu
Application Number:
JP2008552177A
Publication Date:
April 03, 2013
Filing Date:
December 28, 2007
Export Citation:
Assignee:
Nitto Boseki Co., Ltd.
NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES
NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES
International Classes:
C12N15/09; A01K67/04; C12N9/16; G01N33/15; G01N33/50
Domestic Patent References:
| JP2005095063A | 2005-04-14 | |||
| JP2006137739A | 2006-06-01 | |||
| JP2005095063A | 2005-04-14 | |||
| JP2006137739A | 2006-06-01 |
Other References:
JPN6008003424; Ｊｅｎｎｙ Ｌｊｕｓｂｅｒｇ， Ｙｕｎｌｉｎｇ Ｗａｎｇ， Ｐｅｒｎｉｌｌａ Ｌａｎｇ， Ｍａｒｉａ Ｎｏｒｇａｒｄ， Ｒｏｂｅｒｔ Ｄｏｄｄ， Ｋｊｅｌｌ Ｈｕｌｔｅｎｂｙ， Ｂａｒｂｒｏ Ｅｋ-Ｒ: 'Ｐｒｏｔｅｏｌｙｔｉｃ Ｅｘｃｉｓｉｏｎ ｏｆ Ｒｅｐｒｅｓｓｉｖｅ Ｌｏｏｐ Ｄｏｍａｉｎ ｉｎ Ｔａｒｔｒａｔｅ-ｒｅｓｉｓｔａｎｔ Ａｃｉｄ Ｐｈｏｓｐｈａｔａｓｅ ｂｙ Ｃａｔｈｅｐｓｉｎ Ｋ' Ｊ．Ｂｉｏｌ．Ｃｈｅｍ． Ｖｏｌ．２８０, 2005, ｐ．２８３７０-２８３８１
JPN6008003425; Ｍｏｒｉｋａｚｕ Ｉｍａｍｕｒａ， Ｊｕｎｉｃｈｉ Ｎａｋａｉ， Ｓａｔｏｓｈｉ Ｉｎｏｕｅ， Ｇｕｏ Ｘｉｎｇ Ｑｕａｎ， Ｔｏｓｈｉｏ Ｋａｎｄａ ａｎｄ Ｔｏｓｈｉｋｉ Ｔａｍｕｒａ: 'Ｔａｒｇｅｔｅｄ Ｇｅｎｅ Ｅｘｐｒｅｓｓｉｏｎ Ｕｓｉｎｇ ｔｈｅ Ｇａｌ４／ＵＡＳ ｓｙｓｔｅｍ ｉｎ ｔｈｅ Ｓｉｌｋｗｏｒｍ Ｂｏｍｂｙｘ ｍｏｒｉ' Ｇｅｎｅｔｉｃｓ Ｖｏｌ．１６５, 2003, ｐ．１３２９-１３４０
JPN6008003424; Ｊｅｎｎｙ Ｌｊｕｓｂｅｒｇ， Ｙｕｎｌｉｎｇ Ｗａｎｇ， Ｐｅｒｎｉｌｌａ Ｌａｎｇ， Ｍａｒｉａ Ｎｏｒｇａｒｄ， Ｒｏｂｅｒｔ Ｄｏｄｄ， Ｋｊｅｌｌ Ｈｕｌｔｅｎｂｙ， Ｂａｒｂｒｏ Ｅｋ-Ｒ: 'Ｐｒｏｔｅｏｌｙｔｉｃ Ｅｘｃｉｓｉｏｎ ｏｆ Ｒｅｐｒｅｓｓｉｖｅ Ｌｏｏｐ Ｄｏｍａｉｎ ｉｎ Ｔａｒｔｒａｔｅ-ｒｅｓｉｓｔａｎｔ Ａｃｉｄ Ｐｈｏｓｐｈａｔａｓｅ ｂｙ Ｃａｔｈｅｐｓｉｎ Ｋ' Ｊ．Ｂｉｏｌ．Ｃｈｅｍ． Ｖｏｌ．２８０, 2005, ｐ．２８３７０-２８３８１
JPN6008003425; Ｍｏｒｉｋａｚｕ Ｉｍａｍｕｒａ， Ｊｕｎｉｃｈｉ Ｎａｋａｉ， Ｓａｔｏｓｈｉ Ｉｎｏｕｅ， Ｇｕｏ Ｘｉｎｇ Ｑｕａｎ， Ｔｏｓｈｉｏ Ｋａｎｄａ ａｎｄ Ｔｏｓｈｉｋｉ Ｔａｍｕｒａ: 'Ｔａｒｇｅｔｅｄ Ｇｅｎｅ Ｅｘｐｒｅｓｓｉｏｎ Ｕｓｉｎｇ ｔｈｅ Ｇａｌ４／ＵＡＳ ｓｙｓｔｅｍ ｉｎ ｔｈｅ Ｓｉｌｋｗｏｒｍ Ｂｏｍｂｙｘ ｍｏｒｉ' Ｇｅｎｅｔｉｃｓ Ｖｏｌ．１６５, 2003, ｐ．１３２９-１３４０
JPN6008003425; Ｍｏｒｉｋａｚｕ Ｉｍａｍｕｒａ， Ｊｕｎｉｃｈｉ Ｎａｋａｉ， Ｓａｔｏｓｈｉ Ｉｎｏｕｅ， Ｇｕｏ Ｘｉｎｇ Ｑｕａｎ， Ｔｏｓｈｉｏ Ｋａｎｄａ ａｎｄ Ｔｏｓｈｉｋｉ Ｔａｍｕｒａ: 'Ｔａｒｇｅｔｅｄ Ｇｅｎｅ Ｅｘｐｒｅｓｓｉｏｎ Ｕｓｉｎｇ ｔｈｅ Ｇａｌ４／ＵＡＳ ｓｙｓｔｅｍ ｉｎ ｔｈｅ Ｓｉｌｋｗｏｒｍ Ｂｏｍｂｙｘ ｍｏｒｉ' Ｇｅｎｅｔｉｃｓ Ｖｏｌ．１６５, 2003, ｐ．１３２９-１３４０
JPN6008003424; Ｊｅｎｎｙ Ｌｊｕｓｂｅｒｇ， Ｙｕｎｌｉｎｇ Ｗａｎｇ， Ｐｅｒｎｉｌｌａ Ｌａｎｇ， Ｍａｒｉａ Ｎｏｒｇａｒｄ， Ｒｏｂｅｒｔ Ｄｏｄｄ， Ｋｊｅｌｌ Ｈｕｌｔｅｎｂｙ， Ｂａｒｂｒｏ Ｅｋ-Ｒ: 'Ｐｒｏｔｅｏｌｙｔｉｃ Ｅｘｃｉｓｉｏｎ ｏｆ Ｒｅｐｒｅｓｓｉｖｅ Ｌｏｏｐ Ｄｏｍａｉｎ ｉｎ Ｔａｒｔｒａｔｅ-ｒｅｓｉｓｔａｎｔ Ａｃｉｄ Ｐｈｏｓｐｈａｔａｓｅ ｂｙ Ｃａｔｈｅｐｓｉｎ Ｋ' Ｊ．Ｂｉｏｌ．Ｃｈｅｍ． Ｖｏｌ．２８０, 2005, ｐ．２８３７０-２８３８１
JPN6008003425; Ｍｏｒｉｋａｚｕ Ｉｍａｍｕｒａ， Ｊｕｎｉｃｈｉ Ｎａｋａｉ， Ｓａｔｏｓｈｉ Ｉｎｏｕｅ， Ｇｕｏ Ｘｉｎｇ Ｑｕａｎ， Ｔｏｓｈｉｏ Ｋａｎｄａ ａｎｄ Ｔｏｓｈｉｋｉ Ｔａｍｕｒａ: 'Ｔａｒｇｅｔｅｄ Ｇｅｎｅ Ｅｘｐｒｅｓｓｉｏｎ Ｕｓｉｎｇ ｔｈｅ Ｇａｌ４／ＵＡＳ ｓｙｓｔｅｍ ｉｎ ｔｈｅ Ｓｉｌｋｗｏｒｍ Ｂｏｍｂｙｘ ｍｏｒｉ' Ｇｅｎｅｔｉｃｓ Ｖｏｌ．１６５, 2003, ｐ．１３２９-１３４０
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto