Title:
ベンゾチアゾール誘導体
Document Type and Number:
Japanese Patent JP5202946
Kind Code:
B2
Abstract:
The present invention relates to compounds of formulae IA and IB wherein R1 and R2 are each independently lower alkyl or -(CH2)m-O-lower alkyl, or together with the N atom to which they are attached form a heterocyclic ring; R3 is hydrogen or lower alkyl; R4 is lower alkyl; hetaryl is 3H-imidazole-2,4-diyl or 1H-pyrazole-1,4-diyl; n is 1 or 2; and m is 1 or 2; and to pharmaceutically acceptable acid addition salts thereof. These compounds may be used for the treatment of Alzheimer's disease, Parkinson's disease, Huntington's disease, neuroprotection, schizophrenia, anxiety, pain, respiration deficits, depression, ADHD, drug addiction, such as amphetamine, cocaine, opioids, ethanol, nicotine, cannabinoids, or for the treatment of asthma, allergic responses, hypoxia, ischaemia, seizure and substance abuse, or for use as sedatives, muscle relaxants, antipsychotics, antiepileptics, anticonvulsants and cardiaprotective agents for coronary artery disease and heart failure.
Inventors:
Flor, alexander
Reamel, claus
Reamel, claus
Application Number:
JP2007521857A
Publication Date:
June 05, 2013
Filing Date:
July 13, 2005
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D417/12; A61K31/5377; A61P9/02; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/32; A61P25/34; A61P25/36; A61P37/08; A61P43/00
Domestic Patent References:
| JP2003535887A |
Attorney, Agent or Firm:
Hajime Tsukuni
Fusayuki Saito
Keiko Ozawa
Fusayuki Saito
Keiko Ozawa