Title:
シクロパミンアナログ及びその使用方法
Document Type and Number:
Japanese Patent JP5204486
Kind Code:
B2
Abstract:
The present invention provides a preparation method for analogs of cyclopamine of formula 1
that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations.
The compounds of the present invention are particularly useful in treating cancers.
Inventors:
Adams, Julian
Castro, Alfredo Sea.
Foley, Michael A.
Janard Danan Nyar, Somalajan Nyar
Neverinen, Malta
Porter, James Earl.
Trenbrae, Martin
Castro, Alfredo Sea.
Foley, Michael A.
Janard Danan Nyar, Somalajan Nyar
Neverinen, Malta
Porter, James Earl.
Trenbrae, Martin
Application Number:
JP2007530162A
Publication Date:
June 05, 2013
Filing Date:
August 26, 2005
Export Citation:
Assignee:
Infinity Pharmaceuticals, Inc.
International Classes:
C07D491/048; A61K31/4355; A61K31/58; A61K45/00; A61P35/00; A61P35/02; A61P43/00; C07J69/00
Domestic Patent References:
| JP2003517279A | ||||
| JP2003519178A |
Other References:
Science,1998年,280,1603-1607
Genes Dev.,2002年,16,2743-2748
Genes Dev.,2002年,16,2743-2748
Attorney, Agent or Firm:
Kato Asamichi