2-アリール-酢酸、その誘導体、及びそれらを含有する医薬組成物

Japanese Patent JP5208411

B2

Selected 2-arylacetic acids, their derivatives and pharmaceutical compositions that contain these compounds are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2-membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. In particular, 2(ortho)-substituted arylacetic acids or their derivatives, such as amides and sulfonamides, lack cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.

Morriconi, Alessio
Alegretti, Marcello
Bertini, ricardo
Chester, Maria Candida
Bizari, chinsia
Colotta, Francesco

JP2006501731A

June 12, 2013

February 04, 2004

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Dompe Fa.le.Ma Sochieta per Azioni

A61K31/192; A61K31/165; A61K31/196; A61K31/40; A61K31/404; A61K31/407; A61K31/4453; A61K31/5377; A61P1/04; A61P9/10; A61P11/00; A61P13/12; A61P17/06; A61P19/02; A61P35/00; C07C59/205; C07C63/04; C07C65/32; C07C311/02; C07C311/09; C07C311/21; C07C311/29; C07C311/48; C07C311/51; C07D207/30; C07D207/32; C07D207/337; C07D209/26; C07D209/42; C07D295/12; C07D295/13; C07D471/04

JP50037668B1
JP50039663B1

Sydney H. Dromgoole et al.,Clinical Pharmacology and Therapeutics,1982年 9月,Vol. 32, No. 3,p. 371-377

Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita

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