Title:
チモサポニンBIIの調製方法
Document Type and Number:
Japanese Patent JP5208499
Kind Code:
B2
Abstract:
A method for preparation of Timosaponin BII, which uses Chinese traditional medicine Rhizoma Anemarrhenae or fresh rhizoma or fibrous root of Anemarrhena asphodeloides Bge. as raw material, and comprises isolation of Timosaponin BII by one or more processes selected from solvent extraction, resin adsorption, polyamide chromatography, reversed phase column chromatography, Sephadex LH-20 column chromatography ,etc , combining with conventional drying method such as reduced pressure drying, freeze drying, spray drying, and so on. Timosaponin BII obtained by the present method is of over 90 % purity, and the method is simple, practicable and suitable for industrial production.
More Like This:
| WO/2002/015920 | TREATMENT OF HYPERPROLIFERATIVE DISEASES |
Inventors:
Ma bipin
Chen, Hao
Zion, Chenki
Can, repin
Tsang, Jie
Chen, Hao
Zion, Chenki
Can, repin
Tsang, Jie
Application Number:
JP2007509855A
Publication Date:
June 12, 2013
Filing Date:
April 21, 2005
Export Citation:
Assignee:
Tsong Guo Ren Min Jie Fan Jun Jun Ji Sui Ke Shue Yuan Fang Shei Yang Jiu Su
International Classes:
C07J53/00; A61K36/00; A61K36/896; A61P3/10; A61P39/06; C07J71/00
Domestic Patent References:
| JP2000204043A | ||||
| JP4054194A | ||||
| JP2001518477A | ||||
| JP3123725A |
Other References:
Jianying Zhang,Effect of six steroidal saponins isolated from anemarrhenae rhizoma on platelet aggregation and hemolysis in human blood,Clinica Chimica Acta,1999年,289(1-2),p. 79-88
NAKASHIMA, N.,Isolation of Pseudoprototimosaponin AIII from Rhizomes of Anemarrhena asphodeloides and Its Hypoglycemic Activity in Streptozotocin-Induced Diabetic Mice,Journal of Natural Products,1993年,56(3),p. 345-350
SAITO, S.,New Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides BUNGE (Liliaceae),Chemical & pharmaceutical bulletin,1994年,42(11),p. 2342-2345
南雲清二,知母のサポニン成分について,薬学雑誌,1991年,111(6),p. 306-310
MA, B.,Studies on the furostanol saponins from Anemarrhena asphodeloides Bunge,Yaoxue Xuebao,1996年,31(4),p. 271-277
MENG, Z.,Steroidal Saponins from Anemarrhena asphodeloides and their Effects on Superoxide Generation,Planta Medica,1999年,65(7),p. 661-663
Planta Medica,1999年,65(7),661-663
NAKASHIMA, N.,Isolation of Pseudoprototimosaponin AIII from Rhizomes of Anemarrhena asphodeloides and Its Hypoglycemic Activity in Streptozotocin-Induced Diabetic Mice,Journal of Natural Products,1993年,56(3),p. 345-350
SAITO, S.,New Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides BUNGE (Liliaceae),Chemical & pharmaceutical bulletin,1994年,42(11),p. 2342-2345
南雲清二,知母のサポニン成分について,薬学雑誌,1991年,111(6),p. 306-310
MA, B.,Studies on the furostanol saponins from Anemarrhena asphodeloides Bunge,Yaoxue Xuebao,1996年,31(4),p. 271-277
MENG, Z.,Steroidal Saponins from Anemarrhena asphodeloides and their Effects on Superoxide Generation,Planta Medica,1999年,65(7),p. 661-663
Planta Medica,1999年,65(7),661-663
Attorney, Agent or Firm:
Okabe
Masao Okabe
Nobuaki Kato
Shinichi Usui
Ikuo Fujino
Takao Ochi
Norimichi Takanashi
Tsuneo Kobayashi
Masami Saito
Katsuhiko Kimura
Masao Okabe
Nobuaki Kato
Shinichi Usui
Ikuo Fujino
Takao Ochi
Norimichi Takanashi
Tsuneo Kobayashi
Masami Saito
Katsuhiko Kimura