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Title:
逆溶媒を使用する逆転写酵素阻害剤の結晶化方法
Document Type and Number:
Japanese Patent JP5295190
Kind Code:
B2
Abstract:
A method for crystallising (-)-6-chloro-4-cyclopropyl ethynyl 4-trifluoromethyl- 1,4-dihydro-2H- 3,1-benzoxazin-2-one of formula (I) comprises dissolving (I) in a solvent, then adding an antisolvent to initiate crystallisation. Also claimed are Forms I, II and III of (I).

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Inventors:
William Clark
Louis S. Crotzker
Jiojifu El Kukula The Second
Application Number:
JP2010202879A
Publication Date:
September 18, 2013
Filing Date:
September 10, 2010
Export Citation:
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Assignee:
Merck Sharp & Dohme Corp.
International Classes:
C07D265/18; A61K9/14; C12N9/99; A61K31/536; A61P43/00; B01D9/00; C12N9/00; C07D
Domestic Patent References:
JP6184124A
Foreign References:
WO1996022955A1
WO1996037457A1
Other References:
THOMPSON, A. S., et al.,Use of an Ephedrine Alkoxide to Mediate Enantioselective Addition of an Acetylide to a Prochiral Ket,Tetrahedron Lett.,1995年,36(49),pp.8937-8940
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama



 
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