Title:
GIRKチャネル遺伝子解析による薬物感受性の評価方法
Document Type and Number:
Japanese Patent JP5308644
Kind Code:
B2
Abstract:
A method of evaluating drug sensitivity or disease vulnerability, includes linking a gene polymorphism in a GIRK channel gene or a haplotype comprising the gene polymorphism to individual drug sensitivity or individual disease vulnerability.
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Inventors:
Kazutaka Ikeda
Hayashida Makoto
Daisuke Nishizawa
Ichiro Sora
Hayashida Makoto
Daisuke Nishizawa
Ichiro Sora
Application Number:
JP2007221298A
Publication Date:
October 09, 2013
Filing Date:
August 28, 2007
Export Citation:
Assignee:
Tokyo Metropolitan Institute of Medical Science
International Classes:
C12N15/09; C12M1/00; C12Q1/68; G01N33/53; G01N37/00
Domestic Patent References:
| JP2003000258A |
Other References:
TANIZAWA, Y. et al.,"A human pancreatic islet inwardly rectifying potassium channel: cDNA cloning, determination of the genomic structure and genetic variations in Japanese NIDDM patients.",DIABETOLOGIA,1996年 4月,Vol.39, No.4,P.447-452
VAUGHN, J. et al.,"Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3).",BIOCHEM. BIOPHYM. RES. COMMUN.,2000年 8月 2日,Vol.274, No.2,P.302-309
IKEDA, K. et al.,"Molecular mechanisms of analgesia induced by opioids and ethanol: is the GIRK channel one of the keys?",NEUROSCI. RES.,2002年10月,Vol.44, No.2,P.121-131
BLEDNOV, Y.A. et al.,"A pervasive mechanism for analgesia: activation of GIRK2 channels.",PROC. NATL. ACAD. SCI. USA,2003年 1月 7日,Vol.100, No.1,P.277-282
OCANA, M. et al.,"Potassium channels and pain: present realities and future opportunities.",EUR. J. PHARMACOL.,2004年10月 1日,Vol.500, No.1-3,P.203-219
MARKER, C.L. et al.,"Spinal G-protein-gated K+ channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia.",J. NEUROSCI.,2004年 3月17日,Vol.24, No.11,P.2806-2812
VAUGHN, J. et al.,"Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3).",BIOCHEM. BIOPHYM. RES. COMMUN.,2000年 8月 2日,Vol.274, No.2,P.302-309
IKEDA, K. et al.,"Molecular mechanisms of analgesia induced by opioids and ethanol: is the GIRK channel one of the keys?",NEUROSCI. RES.,2002年10月,Vol.44, No.2,P.121-131
BLEDNOV, Y.A. et al.,"A pervasive mechanism for analgesia: activation of GIRK2 channels.",PROC. NATL. ACAD. SCI. USA,2003年 1月 7日,Vol.100, No.1,P.277-282
OCANA, M. et al.,"Potassium channels and pain: present realities and future opportunities.",EUR. J. PHARMACOL.,2004年10月 1日,Vol.500, No.1-3,P.203-219
MARKER, C.L. et al.,"Spinal G-protein-gated K+ channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia.",J. NEUROSCI.,2004年 3月17日,Vol.24, No.11,P.2806-2812
Attorney, Agent or Firm:
Takeshi Takamatsu
Toshiyuki Ozawa
Toshiyuki Ozawa