Title:
有核赤血球濃縮回収用チップ及び有核赤血球濃縮回収方法
Document Type and Number:
Japanese Patent JP5311356
Kind Code:
B2
Abstract:
Provided is a chip or the like having a particulate concentrating mechanism such as a mechanism that can selectively concentrate nucleated red blood cells contained in maternal blood and derived from a fetus and can collect the concentrated liquid rich in nucleated red blood cells, and also provided is a nucleated red blood cell concentrating/collecting method. A micro-channel chip for concentrating nucleated red blood cells has an inlet-side channel, an outlet-side channel, and a separation narrow channel provided between the inlet-side channel and the outlet-side channel. The separation narrow channel has an inner wall having a dimension through which non-nucleated red blood cells easily pass and nucleated red blood cells hardly pass, and has a means for deforming or moving part of the inner wall of the channel to have a dimension through which nucleated red blood cells easily pass. The following are also provided: a method for collecting a liquid in which nucleated red blood cells obtained by using this chip are concentrated; and a micro-channel chip for concentrating particulates other than for concentrating nucleated red blood cells.
Inventors:
Takeshi Kumo
Takamura Zen
Haruo Takabayashi
Takamura Zen
Haruo Takabayashi
Application Number:
JP2011529943A
Publication Date:
October 09, 2013
Filing Date:
September 02, 2010
Export Citation:
Assignee:
National University Corporation Japan Advanced Institute of Science and Technology
Kanazawa Medical University
Kanazawa Medical University
International Classes:
G01N35/08; B01J19/00; C12M1/00; C12N5/078; G01N1/34; G01N37/00; G01N33/48
Domestic Patent References:
| JPH03257366A | 1991-11-15 | |||
| JPH02130471A | 1990-05-18 | |||
| JP2006145345A | 2006-06-08 | |||
| JP2003525101A | 2003-08-26 | |||
| JP2009504154A | 2009-02-05 | |||
| JP2006501449A | 2006-01-12 | |||
| JP2005000851A | 2005-01-06 |
Foreign References:
| WO2008011486A2 | 2008-01-24 |
Other References:
JPN6010063193; Ｍｏｈａｍｅｄ， Ｈ． ｅｔ ａｌ．: 'Ｂｉｏｃｈｉｐ ｆｏｒ ｓｅｐａｒａｔｉｎｇ ｆｅｔａｌ ｃｅｌｌｓ ｆｒｏｍ ｍａｔｅｒｎａｌ ｃｉｒｃｕｌａｔｉｏｎ．' Ｊ Ｃｈｒｏｍａｔｏｇｒ Ａ Ｖｏｌ．１１６２（２）, 2007, ｐ．１８７-１９２
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes