Title:
LOXおよびLOXL2阻害剤ならびにこれらの使用
Document Type and Number:
Japanese Patent JP5312459
Kind Code:
B2
Abstract:
The present disclosure provides innovative methodology and related compositions and kits for preventing and treating various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using an inhibitor of processed forms of lysyl oxidase or lysyl oxidase-like proteins, an inhibitor of LOX and an inhibitor of a LOXL, or a synergistic combination of an inhibitor of LOX or LOXL combined with other therapeutic agents. Also provided are innovative methods for selecting agents that prevent or inhibit tumor invasion, angiogenesis and metastasis, by contacting cells that are in an epithelial-mesenchymal transition (EMT) state with a candidate agent and detecting a change in the EMT state of the cells. Methods and related compositions and kits for diagnosing or monitoring various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using molecules or agents that specifically recognize processed forms of LOX or LOXL are also provided. Also provided herein are methods and related compositions, medical devices, systems and kits for preventing or treating various diseases and conditions associated with fibrosis with compositions comprising inhibitors of LOX or LOXL. Such diseases or conditions include pathological cardiovascular conditions and diseases such as hypertension, hypertensive heart disease, myocardial infarction, atherosclerosis, and restenosis, liver fibrosis, kidney fibrosis, lung fibrosis, dermal scaring, keloid formation, and Alzheimer's disease.
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Inventors:
Smith, victoria
Scott Ogg
Van Brasserie, Peter
Barry, Vivian Yee.
Marshall, Derek
Holson, Allison Kay
Rodriguez, Hector
Oho Miho
Macquarie, Scott Alan
Carlos Aurelio, Garcia
Biman, Donna Hiroko Tokuoka
Scott Ogg
Van Brasserie, Peter
Barry, Vivian Yee.
Marshall, Derek
Holson, Allison Kay
Rodriguez, Hector
Oho Miho
Macquarie, Scott Alan
Carlos Aurelio, Garcia
Biman, Donna Hiroko Tokuoka
Application Number:
JP2010519263A
Publication Date:
October 09, 2013
Filing Date:
August 01, 2008
Export Citation:
Assignee:
Jilled Biologics, Inc.
International Classes:
C07K16/40; A61K39/395; A61K45/00; A61P1/04; A61P1/16; A61P1/18; A61P9/00; A61P11/00; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P19/00; A61P21/00; A61P25/00; A61P35/00; A61P35/04; A61P43/00; G01N33/573; G01N33/574; C12N15/09; C12P21/08
Other References:
The EMBO J., 2005, Vol.24, pp.3446-3458
Attorney, Agent or Firm:
Naoto Uchida
Koji Okuhara
Koji Okuhara