Title:
血管形成のsiRNA阻害のための組成物及び方法
Document Type and Number:
Japanese Patent JP5337337
Kind Code:
B2
Abstract:
The present invention relates to RNA interference using small interfering RNAs (siRNAs) which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt1 and Flk-I/KDR and which inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
Inventors:
Michael Jay Trentino
Samuel Joesome Like
Samuel Joesome Like
Application Number:
JP2004523550A
Publication Date:
November 06, 2013
Filing Date:
July 18, 2003
Export Citation:
Assignee:
AstraZeneca UK Limited
International Classes:
C12N15/113; A61K31/7105; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C12N5/10; A61K38/00
Domestic Patent References:
| JP9503651A |
Foreign References:
| WO2000008141A1 | ||||
| WO2001068336A1 | ||||
| WO2001075164A1 | ||||
| WO2002044321A1 |
Other References:
Am.J.Physiol.Heart Circ.Physiol.(2002)Vol.282,No.1,p.194-204
Attorney, Agent or Firm:
Motohiro Kurauchi
Axis International Patent Business Corporation
Axis International Patent Business Corporation