Title:
多重修飾されたゼラチン誘導体およびその架橋材料
Document Type and Number:
Japanese Patent JP5357779
Kind Code:
B2
Abstract:
The disclosed is a kind of multiple modified derivatives of gelatin having not only the structure of formula (I) but also one of structures of formula (II), (III), and (IV) as well. Wherein, G refers to gelatin residue comprising type A, type B and the type of gene recombination; R 1 refers to allylene, or a linkage group with amide; R 2 refers to alkyl, or aryl; R 3 refers to alkylene; R 4 refers to carboxyl or carboxylate. The multiple modifying ways of gelatin comprise the hydrophobic modification on the amino group of gelatin through amide bond, carboxylation on the amino group of gelatin through amide bond, thiolation on the carboxyl group of gelatin, and thiolation following carboxylation on amino group of gelatin through amide bond. In addition, the invention also discloses the crosslinked material made of multiple modified derivatives of gelatin. The multiple modified derivatives of gelatin have flexible chemical structures and many properties. Their crosslinked gelatin material can be used the matrix for cell growth etc.
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Inventors:
Song Song
Application Number:
JP2009545047A
Publication Date:
December 04, 2013
Filing Date:
September 29, 2007
Export Citation:
Assignee:
BIOREGEN BIOMEDICAL (CHANGZHOU) Co., Ltd.
International Classes:
C09H5/00; C07K14/78; C08H1/06
Domestic Patent References:
| JP6073341A | ||||
| JP6100700A | ||||
| JP2006133365A | ||||
| JP2006349726A | ||||
| JP2010512433A |
Foreign References:
| WO2004037164A1 |
Other References:
Biochem J.,1958年,p.458-468
Bioconjugate Chem.,2005年,16,p.1423-1432
Bioconjugate Chem.,2005年,16,p.1423-1432
Attorney, Agent or Firm:
Koichi Washida