Title:
骨補填剤,放出制御担体,及びそれらの製造方法
Document Type and Number:
Japanese Patent JP5405119
Kind Code:
B2
Abstract:
A bone filling material having controlled release of a pharmaceutical agent such as a growth factor, and a drug release controlling carrier having controlled release of a pharmaceutical agent is provided by inactivating a functional group which can strongly bind to the pharmaceutical agent of the bone filling material with a blocking agent. The bone filling material and the drug release controlling carrier of the present invention comprises: a calcium-based material such as hydroxyapatite, carbonate apatite, fluorapatite, chlorapatite, ²-TCP, and ±-TCP; a blocking agent of the calcium-based material such as serine and dextran; and a pharmaceutical agent.
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Inventors:
Nobuo Sasaki
Chung, Ung-il
Kazuyo Ikawa
Shigeki Suzuki
Kotaro Shimizu
Chung, Ung-il
Kazuyo Ikawa
Shigeki Suzuki
Kotaro Shimizu
Application Number:
JP2008546869A
Publication Date:
February 05, 2014
Filing Date:
November 08, 2007
Export Citation:
Assignee:
Next 21 Co., Ltd.
International Classes:
A61L27/00
Domestic Patent References:
| JPH06329557A | 1994-11-29 | |||
| JP2006095302A | 2006-04-13 | |||
| JPH06329557A | 1994-11-29 | |||
| JP2006095302A | 2006-04-13 |
Foreign References:
| WO2003018690A1 | 2003-03-06 | |||
| WO2003018690A1 | 2003-03-06 |
Other References:
JPN6008015285; Ｍ． Ｓｈｉｒｋｈａｎｚａｄｅｈ: 'Ｂｉｏｃｏｍｐａｔｉｂｌｅ ｄｅｌｉｖｅｒｙ ｓｙｓｔｅｍｓ ｆｏｒ ｏｓｔｅｏｉｎｄｕｃｔｉｖｅ ｐｒｏｔｅｉｎｓ： ｉｍｍｏｂｉｌｉｚａｔｉｏｎ ｏｆ Ｌ-ｌｙｓｉｎｅ ｉｎ ｍｉｃｒｏ-ｐｏｒｏ' Ｍａｔｅｒｉａｌ Ｌｅｔｔｅｒｓ ｖｏｌ．２１， ｎｏ．１, 1994, ｐｐ．１１５-１１８
JPN6008015282; Ａ． Ｌｅｂｕｇｌｅ ｅｔ ａｌ: 'Ｓｔｕｄｙ ｏｆ ｉｍｐｌａｎｔａｂｌｅ ｃａｌｃｉｕｍ ｐｈｏｓｐｈａｔｅ ｓｙｓｔｅｍｓ ｆｏｒ ｔｈｅ ｓｌｏｗ ｒｅｌｅａｓｅ ｏｆ ｍｅｔｈｏｔｒｅｘａｔｅ' Ｂｉｏｍａｔｅｒｉａｌｓ ｖｏｌ．２３， ｎｏ．１６, 2002, ｐｐ．３５１７-３５２２
JPN6008015283; Ｃ． Ｃ． Ｒｉｂｅｉｒｏ ｅｔ ａｌ: 'Ｃａｌｃｉｕｍ ｐｈｏｓｐｈａｔｅ-ａｌｇｉｎａｔｅ ｍｉｃｒｏｓｐｈｅｒｅｓ ａｓ ｅｎｚｙｍｅ ｄｅｌｉｖｅｒｙ ｍａｔｒｉｃｅｓ' Ｂｉｏｍａｔｅｒｉａｌｓ ｖｏｌ．２５， ｎｏ．１８, 2004, ｐｐ．４３６３-４３７３
JPN6008015284; 門間英毅: 'ジカルボン酸複合アパタイト系層間化合物' 石膏と石灰 ｎｏ．２３７, 1992, ｐｐ．１０８-１１４
JPN6008015286; Ａ． Ｌｏｄｅ ｅｔ ａｌ: 'Ｃａｌｃｉｕｍ ｐｈｏｓｐｈａｔｅ ｂｏｎｅ ｃｅｍｅｎｔｓ， ｆｕｎｃｔｉｏｎａｌｉｚｅｄ ｗｉｔｈ ＶＥＧＦ： ｒｅｌｅａｓｅ ｋｉｎｅｔｉｃｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ａｃｔｉｖｉｔｙ' Ｊ Ｂｉｏｍｅｄ Ｍａｔｅｒ Ｒｅｓ Ｐｔ Ａ ｖｏｌ．８１， ｎｏ．２, 20061128, ｐｐ．４７４-４８３
JPN6008015282; Ａ． Ｌｅｂｕｇｌｅ ｅｔ ａｌ: 'Ｓｔｕｄｙ ｏｆ ｉｍｐｌａｎｔａｂｌｅ ｃａｌｃｉｕｍ ｐｈｏｓｐｈａｔｅ ｓｙｓｔｅｍｓ ｆｏｒ ｔｈｅ ｓｌｏｗ ｒｅｌｅａｓｅ ｏｆ ｍｅｔｈｏｔｒｅｘａｔｅ' Ｂｉｏｍａｔｅｒｉａｌｓ ｖｏｌ．２３， ｎｏ．１６, 2002, ｐｐ．３５１７-３５２２
JPN6008015283; Ｃ． Ｃ． Ｒｉｂｅｉｒｏ ｅｔ ａｌ: 'Ｃａｌｃｉｕｍ ｐｈｏｓｐｈａｔｅ-ａｌｇｉｎａｔｅ ｍｉｃｒｏｓｐｈｅｒｅｓ ａｓ ｅｎｚｙｍｅ ｄｅｌｉｖｅｒｙ ｍａｔｒｉｃｅｓ' Ｂｉｏｍａｔｅｒｉａｌｓ ｖｏｌ．２５， ｎｏ．１８, 2004, ｐｐ．４３６３-４３７３
JPN6008015284; 門間英毅: 'ジカルボン酸複合アパタイト系層間化合物' 石膏と石灰 ｎｏ．２３７, 1992, ｐｐ．１０８-１１４
JPN6008015286; Ａ． Ｌｏｄｅ ｅｔ ａｌ: 'Ｃａｌｃｉｕｍ ｐｈｏｓｐｈａｔｅ ｂｏｎｅ ｃｅｍｅｎｔｓ， ｆｕｎｃｔｉｏｎａｌｉｚｅｄ ｗｉｔｈ ＶＥＧＦ： ｒｅｌｅａｓｅ ｋｉｎｅｔｉｃｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ａｃｔｉｖｉｔｙ' Ｊ Ｂｉｏｍｅｄ Ｍａｔｅｒ Ｒｅｓ Ｐｔ Ａ ｖｏｌ．８１， ｎｏ．２, 20061128, ｐｐ．４７４-４８３
JPN6008015285; Ｍ． Ｓｈｉｒｋｈａｎｚａｄｅｈ: 'Ｂｉｏｃｏｍｐａｔｉｂｌｅ ｄｅｌｉｖｅｒｙ ｓｙｓｔｅｍｓ ｆｏｒ ｏｓｔｅｏｉｎｄｕｃｔｉｖｅ ｐｒｏｔｅｉｎｓ： ｉｍｍｏｂｉｌｉｚａｔｉｏｎ ｏｆ Ｌ-ｌｙｓｉｎｅ ｉｎ ｍｉｃｒｏ-ｐｏｒｏ' Ｍａｔｅｒｉａｌ Ｌｅｔｔｅｒｓ ｖｏｌ．２１， ｎｏ．１, 1994, ｐｐ．１１５-１１８
JPN6008015282; Ａ． Ｌｅｂｕｇｌｅ ｅｔ ａｌ: 'Ｓｔｕｄｙ ｏｆ ｉｍｐｌａｎｔａｂｌｅ ｃａｌｃｉｕｍ ｐｈｏｓｐｈａｔｅ ｓｙｓｔｅｍｓ ｆｏｒ ｔｈｅ ｓｌｏｗ ｒｅｌｅａｓｅ ｏｆ ｍｅｔｈｏｔｒｅｘａｔｅ' Ｂｉｏｍａｔｅｒｉａｌｓ ｖｏｌ．２３， ｎｏ．１６, 2002, ｐｐ．３５１７-３５２２
JPN6008015283; Ｃ． Ｃ． Ｒｉｂｅｉｒｏ ｅｔ ａｌ: 'Ｃａｌｃｉｕｍ ｐｈｏｓｐｈａｔｅ-ａｌｇｉｎａｔｅ ｍｉｃｒｏｓｐｈｅｒｅｓ ａｓ ｅｎｚｙｍｅ ｄｅｌｉｖｅｒｙ ｍａｔｒｉｃｅｓ' Ｂｉｏｍａｔｅｒｉａｌｓ ｖｏｌ．２５， ｎｏ．１８, 2004, ｐｐ．４３６３-４３７３
JPN6008015284; 門間英毅: 'ジカルボン酸複合アパタイト系層間化合物' 石膏と石灰 ｎｏ．２３７, 1992, ｐｐ．１０８-１１４
JPN6008015286; Ａ． Ｌｏｄｅ ｅｔ ａｌ: 'Ｃａｌｃｉｕｍ ｐｈｏｓｐｈａｔｅ ｂｏｎｅ ｃｅｍｅｎｔｓ， ｆｕｎｃｔｉｏｎａｌｉｚｅｄ ｗｉｔｈ ＶＥＧＦ： ｒｅｌｅａｓｅ ｋｉｎｅｔｉｃｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ａｃｔｉｖｉｔｙ' Ｊ Ｂｉｏｍｅｄ Ｍａｔｅｒ Ｒｅｓ Ｐｔ Ａ ｖｏｌ．８１， ｎｏ．２, 20061128, ｐｐ．４７４-４８３
JPN6008015282; Ａ． Ｌｅｂｕｇｌｅ ｅｔ ａｌ: 'Ｓｔｕｄｙ ｏｆ ｉｍｐｌａｎｔａｂｌｅ ｃａｌｃｉｕｍ ｐｈｏｓｐｈａｔｅ ｓｙｓｔｅｍｓ ｆｏｒ ｔｈｅ ｓｌｏｗ ｒｅｌｅａｓｅ ｏｆ ｍｅｔｈｏｔｒｅｘａｔｅ' Ｂｉｏｍａｔｅｒｉａｌｓ ｖｏｌ．２３， ｎｏ．１６, 2002, ｐｐ．３５１７-３５２２
JPN6008015283; Ｃ． Ｃ． Ｒｉｂｅｉｒｏ ｅｔ ａｌ: 'Ｃａｌｃｉｕｍ ｐｈｏｓｐｈａｔｅ-ａｌｇｉｎａｔｅ ｍｉｃｒｏｓｐｈｅｒｅｓ ａｓ ｅｎｚｙｍｅ ｄｅｌｉｖｅｒｙ ｍａｔｒｉｃｅｓ' Ｂｉｏｍａｔｅｒｉａｌｓ ｖｏｌ．２５， ｎｏ．１８, 2004, ｐｐ．４３６３-４３７３
JPN6008015284; 門間英毅: 'ジカルボン酸複合アパタイト系層間化合物' 石膏と石灰 ｎｏ．２３７, 1992, ｐｐ．１０８-１１４
JPN6008015286; Ａ． Ｌｏｄｅ ｅｔ ａｌ: 'Ｃａｌｃｉｕｍ ｐｈｏｓｐｈａｔｅ ｂｏｎｅ ｃｅｍｅｎｔｓ， ｆｕｎｃｔｉｏｎａｌｉｚｅｄ ｗｉｔｈ ＶＥＧＦ： ｒｅｌｅａｓｅ ｋｉｎｅｔｉｃｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ａｃｔｉｖｉｔｙ' Ｊ Ｂｉｏｍｅｄ Ｍａｔｅｒ Ｒｅｓ Ｐｔ Ａ ｖｏｌ．８１， ｎｏ．２, 20061128, ｐｐ．４７４-４８３
JPN6008015285; Ｍ． Ｓｈｉｒｋｈａｎｚａｄｅｈ: 'Ｂｉｏｃｏｍｐａｔｉｂｌｅ ｄｅｌｉｖｅｒｙ ｓｙｓｔｅｍｓ ｆｏｒ ｏｓｔｅｏｉｎｄｕｃｔｉｖｅ ｐｒｏｔｅｉｎｓ： ｉｍｍｏｂｉｌｉｚａｔｉｏｎ ｏｆ Ｌ-ｌｙｓｉｎｅ ｉｎ ｍｉｃｒｏ-ｐｏｒｏ' Ｍａｔｅｒｉａｌ Ｌｅｔｔｅｒｓ ｖｏｌ．２１， ｎｏ．１, 1994, ｐｐ．１１５-１１８
Attorney, Agent or Firm:
Shirasaka Hajime
Takayuki Hirose
Takayuki Hirose