Title:
二重鎖アクセプターDNA塩基配列の標的化改変のための方法
Document Type and Number:
Japanese Patent JP5405121
Kind Code:
B2
Abstract:
A method and oligonucleotides for targeted nucleotide exchange of a duplex DNA sequence, wherein the donor oligonucleotide contains at least one modified nucleotide having a higher binding affinity compared to naturally occurring A, C, T or G and/or binds stronger to a nucleotide in an opposite position in the first DNA sequence as compared to a naturally occurring nucleotide complementary to the nucleotide in the opposite position in the first DNA sequence.
Inventors:
Bunduk, Paul
Debose, Miheel Theodor Yang
Hohe Health, René Cornelis Josephus
Wachowski, Radvic Kevin
Debose, Miheel Theodor Yang
Hohe Health, René Cornelis Josephus
Wachowski, Radvic Kevin
Application Number:
JP2008547130A
Publication Date:
February 05, 2014
Filing Date:
December 21, 2006
Export Citation:
Assignee:
Key Jean NAMROSE FENNOTE SHAP
International Classes:
C12N15/09; A01H1/00; A01H5/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Domestic Patent References:
| JP2003528607A |
Foreign References:
| WO2001092512A1 |
Other References:
Chem Biol. 2002 Oct;9(10):1073-84.
Nucleic Acids Res Vol.33 No.12 Page.3733-3742 (2005.Jul)
OLIGONUCLEOTIDES,2003年,Vol.13,p.479-489
Nucleic Acids Res Vol.33 No.12 Page.3733-3742 (2005.Jul)
OLIGONUCLEOTIDES,2003年,Vol.13,p.479-489
Attorney, Agent or Firm:
Kenho Ikeda
Shuichi Fukuda
Shuichi Fukuda