Title:
サルモネラ菌及びシート状M細胞
Document Type and Number:
Japanese Patent JP5420791
Kind Code:
B1
Abstract:
[Problem] To provide a detoxified salmonella capable of potentiating a protein that is required for function enhancement in M cells (microfold cells), sheet-type M cells wherein the protein required for function enhancement of M cells has been potentiated by the detoxified salmonella, and an artificial micro organ into which the sheet-type M cells has been introduced. [Solution] A salmonella capable of invading into M cells, said salmonella being detoxified Salmonella (Ty21a) derived, via mutation, from Salmonella (Ty2). This detoxified Salmonella (Ty21a) further carries a gene producing galectin-9 that is capable of enhancing the function of M cells, said gene having been introduced by genetic recombination. Therefore, galectin-9 in the M cells is thus potentiated and, in its turn, enhances the function of the M cells. The detoxified Salmonella (Ty21a) having invaded into the M cells disappears with the passage of time.
Inventors:
Hajime Fukunaga
Takayuki Esaki
Takayuki Esaki
Application Number:
JP2013173685A
Publication Date:
February 19, 2014
Filing Date:
August 23, 2013
Export Citation:
Assignee:
Hajime Fukunaga
International Classes:
C12N1/00; A61L27/00; C12N15/09; C07K14/47
Domestic Patent References:
| JP5197880B1 | 2013-05-15 | |||
| JP2001501831A | 2001-02-13 |
Foreign References:
| WO2012077811A1 | 2012-06-14 |
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Attorney, Agent or Firm:
Yu Koyama