Title:
カルボニルオキシ化合物の製造方法
Document Type and Number:
Japanese Patent JP5441913
Kind Code:
B2
Abstract:
A process for carbonyloxy compound production is provided which comprises reacting an aniline compound with a nitrous acid salt in the presence of an acid to synthesize a diazonium salt and subsequently reacting the diazonium salt with an a,ß-unsaturated carbonyloxy compound in the presence of a copper catalyst to produce the desired carbonyloxy compound. This process is characterized in that the reaction between the diazonium salt and the a,ß-unsaturated carbonyloxy compound is conducted in the presence of a base having an acid dissociation index (pKa) at 25ºC of 7 or lower. According to the process, methyl 2-bromo-3-{4-[2-(5-ethyl-2-pyridyl)ethoxy]phenyl}propionate as an intermediate for a therapeutic agent that produces an excellent effect on type 2 diabetes, which is caused by a deficiency in the action of insulin, and other compounds can be highly efficiently obtained so as to have a high purity.
Inventors:
Kenji Tanaka
Application Number:
JP2010532869A
Publication Date:
March 12, 2014
Filing Date:
September 14, 2009
Export Citation:
Assignee:
Tokuyama Corporation
International Classes:
C07C67/347; C07C69/65; C07C69/732; C07C69/734; C07D213/30; C07D417/12; C07B61/00
Domestic Patent References:
| JP7233120A | ||||
| JP6081143A | ||||
| JP61267580A |
Other References:
SOHDA, T. ET AL.,Studies on Antidiabetic Agents. II. Synthesis of 5-[4-(1- Methylcyclohexylmethoxy)-benzyl]thiazolidine-2,4-dione (ADD-3878) and Its Derivatives,CHEMICAL & PHARMACEUTICAL BULLETIN,1982年,vol. 30, no. 10,p.3580-3600
Attorney, Agent or Firm:
Yasuyo Takahata