Title:
ドーパミン受容体を標的とする薬剤、およびそのスクリーニング方法
Document Type and Number:
Japanese Patent JP5442256
Kind Code:
B2
Abstract:
It is intended to obtain a new finding related to a mechanism of inducing differentiation of Th1/Th2/Th17 through dendritic cells, and to provide a pharmaceutical effective in an immunity-related disease by utilizing the finding, a screening method for the pharmaceutical, and an effective agent for regulating a mechanism of inducing differentiation of Th1/Th2/Th17 through dendritic cells. The invention relates to a pharmaceutical for treating or preventing a disease caused by the imbalance of Th, characterized by containing a compound that modifies the activity of dopamine receptor as an active ingredient, a screening method for the pharmaceutical, and various agents characterized by containing a dopamine D1-like receptor antagonist or a dopamine D2-like receptor antagonist as an active ingredient.
Inventors:
Matsushita Sho
Nakano Kazuhisa
Nakano Kazuhisa
Application Number:
JP2008527793A
Publication Date:
March 12, 2014
Filing Date:
August 02, 2007
Export Citation:
Assignee:
Immuno Co., Ltd.
Educational corporation Saitama Medical University
Educational corporation Saitama Medical University
International Classes:
C12Q1/06; A61K31/40; A61K31/55; A61P3/10; A61P13/12; A61P25/00; A61P29/00; A61P37/02; G01N33/15; C07D207/04; C07D207/06; C07D223/16
Other References:
JPN6012044025; Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｍｍｕｎｏｐｈａｒｍａｃｏｌｏｇｙ， ２００３， Ｖｏｌ．３， Ｎｏ．７， ｐｐ．１０１９-１０２６
JPN6012044026; 日本内分泌学会雑誌， １９８１， Ｖｏｌ．５７， ｐｐ．１７０７-１７１５
JPN6012044029; Ｂｉｏｃｈｅｍｉｃａｌ Ｐｈａｒｍａｃｏｌｏｇｙ， ２００４， Ｖｏｌ．６７， Ｎｏ．５， ｐｐ．８６５-８７３
JPN6012044019; Ｍｅｄｉｃａｌ Ｈｙｐｏｔｈｅｓｅｓ， ２００１， Ｖｏｌ．５７， Ｎｏ．２， ｐｐ．２５８-２７５
JPN6012044021; Ｉｍｍｕｎｏｐｈａｒｍａｃｏｌｏｇｙ， １９９７， Ｖｏｌ．３７， Ｎｏ．１， ｐｐ．７５-８６
JPN6012044023; Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｉｍｍｕｎｏｌｏｇｙ， ２００２， ｖｏｌ．１３０， Ｎｏ．１-２， ｐｐ．５５-６５
JPN6012044019; Ｍｅｄｉｃａｌ Ｈｙｐｏｔｈｅｓｅｓ， ２００１， Ｖｏｌ．５７， Ｎｏ．２， ｐｐ．２５８-２７５
JPN6012044021; Ｉｍｍｕｎｏｐｈａｒｍａｃｏｌｏｇｙ， １９９７， Ｖｏｌ．３７， Ｎｏ．１， ｐｐ．７５-８６
JPN6012044023; Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｉｍｍｕｎｏｌｏｇｙ， ２００２， ｖｏｌ．１３０， Ｎｏ．１-２， ｐｐ．５５-６５
JPN6013017138; Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ， １９９７， Ｖｏｌ．６１， Ｎｏ．１０， ｐｐ．９５１-９５６
JPN6013017140; Ｅｕｒ． Ｊ． Ｐｈａｒｍａｃｏｌｏｇｙ： Ｅｎｖｉｒｏｎｍｅｎｔａｌ Ｔｏｘｉｃｏｌｏｇｙ ａｎｄ Ｐｈａｒｍａｃｏｌｏｇｙ， １９９３， Ｖｏｌ．２４８， Ｎｏ．３， ｐｐ．２１７-２２１
JPN6012044025; Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｍｍｕｎｏｐｈａｒｍａｃｏｌｏｇｙ， ２００３， Ｖｏｌ．３， Ｎｏ．７， ｐｐ．１０１９-１０２６
JPN6012044026; 日本内分泌学会雑誌， １９８１， Ｖｏｌ．５７， ｐｐ．１７０７-１７１５
JPN6012044029; Ｂｉｏｃｈｅｍｉｃａｌ Ｐｈａｒｍａｃｏｌｏｇｙ， ２００４， Ｖｏｌ．６７， Ｎｏ．５， ｐｐ．８６５-８７３
JPN6012044026; 日本内分泌学会雑誌， １９８１， Ｖｏｌ．５７， ｐｐ．１７０７-１７１５
JPN6012044029; Ｂｉｏｃｈｅｍｉｃａｌ Ｐｈａｒｍａｃｏｌｏｇｙ， ２００４， Ｖｏｌ．６７， Ｎｏ．５， ｐｐ．８６５-８７３
JPN6012044019; Ｍｅｄｉｃａｌ Ｈｙｐｏｔｈｅｓｅｓ， ２００１， Ｖｏｌ．５７， Ｎｏ．２， ｐｐ．２５８-２７５
JPN6012044021; Ｉｍｍｕｎｏｐｈａｒｍａｃｏｌｏｇｙ， １９９７， Ｖｏｌ．３７， Ｎｏ．１， ｐｐ．７５-８６
JPN6012044023; Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｉｍｍｕｎｏｌｏｇｙ， ２００２， ｖｏｌ．１３０， Ｎｏ．１-２， ｐｐ．５５-６５
JPN6012044019; Ｍｅｄｉｃａｌ Ｈｙｐｏｔｈｅｓｅｓ， ２００１， Ｖｏｌ．５７， Ｎｏ．２， ｐｐ．２５８-２７５
JPN6012044021; Ｉｍｍｕｎｏｐｈａｒｍａｃｏｌｏｇｙ， １９９７， Ｖｏｌ．３７， Ｎｏ．１， ｐｐ．７５-８６
JPN6012044023; Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｉｍｍｕｎｏｌｏｇｙ， ２００２， ｖｏｌ．１３０， Ｎｏ．１-２， ｐｐ．５５-６５
JPN6013017138; Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ， １９９７， Ｖｏｌ．６１， Ｎｏ．１０， ｐｐ．９５１-９５６
JPN6013017140; Ｅｕｒ． Ｊ． Ｐｈａｒｍａｃｏｌｏｇｙ： Ｅｎｖｉｒｏｎｍｅｎｔａｌ Ｔｏｘｉｃｏｌｏｇｙ ａｎｄ Ｐｈａｒｍａｃｏｌｏｇｙ， １９９３， Ｖｏｌ．２４８， Ｎｏ．３， ｐｐ．２１７-２２１
JPN6012044025; Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｍｍｕｎｏｐｈａｒｍａｃｏｌｏｇｙ， ２００３， Ｖｏｌ．３， Ｎｏ．７， ｐｐ．１０１９-１０２６
JPN6012044026; 日本内分泌学会雑誌， １９８１， Ｖｏｌ．５７， ｐｐ．１７０７-１７１５
JPN6012044029; Ｂｉｏｃｈｅｍｉｃａｌ Ｐｈａｒｍａｃｏｌｏｇｙ， ２００４， Ｖｏｌ．６７， Ｎｏ．５， ｐｐ．８６５-８７３
Attorney, Agent or Firm:
Patent Business Corporation St. Crest International Patent Office
Noriaki Nagahama
Noriaki Nagahama