Title:
キサンチンオキシダーゼ阻害剤
Document Type and Number:
Japanese Patent JP5456757
Kind Code:
B2
Abstract:
The invention relates to compounds of the following formula (I) or their salts:
in which R 1 is a group of phenyl, naphthyl, pyridyl or the like which may have a substituent such as an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, carboxyl, halogen, hydroxyl, nitro, or cyano; R 2 is cyano, nitro, or the like; R 3 is hydroxyl or the like; X is oxygen, sulfur, or the like; and Y is oxygen or sulfur, and a xanthine oxidase inhibitor containing the compound.
Inventors:
Shinichi Yoshida
Kunio Kobayashi
Nobutaka Mochizuki
Tomio Yamakawa
Tadashi Kobayashi
Suzuko Shinohara
Kunio Kobayashi
Nobutaka Mochizuki
Tomio Yamakawa
Tadashi Kobayashi
Suzuko Shinohara
Application Number:
JP2011276232A
Publication Date:
April 02, 2014
Filing Date:
December 16, 2011
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO.,LTD.
International Classes:
C07D513/04; A61K31/519; A61P3/00; A61P19/06; A61P43/00; C07D498/04
Domestic Patent References:
| JP4914210B2 | ||||
| JP3163082A | ||||
| JP2000001431A |
Foreign References:
| WO2003042185A1 | ||||
| WO1992009279A1 | ||||
| WO1998018765A1 |
Other References:
BAKER, B.R. et al.,Irreversible Enzyme Inhibitors. CXXV. Active-Site-Directed Irreversible Inhibitors of Xanthine Oxidase Derived from Arylpurines and Pyrazolo[3,4-d]pyrimidines Bearing a Terminal Sulfonyl Fluoride,J. Med. Chem.,1968年 7月,vol.11,p.656-661
BAKER, B.R. et al.,Irreversible Enzyme Inhibitors. CXXVI. Hydrocarbon Interaction with Xanthine Oxidase by Phenyl Substituents on Purines and Pyrazolo[3,4-d]pyrimidines,J. Med. Chem.,1968年 7月,vol.11,p.661-666
Maryadele J. O'NEIL et al.,THE MERCK INDEX,MERCK & CO.,INC.,2001年,13th edition,p.52-53,276. Allopurinol
BAKER, B.R. et al.,Irreversible Enzyme Inhibitors. CXXVI. Hydrocarbon Interaction with Xanthine Oxidase by Phenyl Substituents on Purines and Pyrazolo[3,4-d]pyrimidines,J. Med. Chem.,1968年 7月,vol.11,p.661-666
Maryadele J. O'NEIL et al.,THE MERCK INDEX,MERCK & CO.,INC.,2001年,13th edition,p.52-53,276. Allopurinol
Attorney, Agent or Firm:
Chikusa Shinichi
Toshihiko Sato
Toshihiko Sato