Title:
ペルオキシソーム増殖剤応答性受容体(PPAR)活性化剤、ならびにそれを用いた医薬、サプリメント、機能性食品および食品添加物
Document Type and Number:
Japanese Patent JP5473191
Kind Code:
B2
Abstract:
The present invention provides a peroxisome proliferator-activated receptor (PPAR) activator, which is free from the problem of side effects, can be taken over a long term and has no characteristics taste. Nobiletin is employed as a PPAR activator. Nobiletin has an excellent PPAR activity and has an excellent adiponectin secretion-promoting effect, and is contained in a large amount in citrus fruits, in particular, in Shiikuwasha (Citrus depressa HAYATA) indigenous to Okinawa (Japan). Since citrus fruits have been consumed for many years, the safety of nobiletin has been proven and besides, nobiletin has a low calorie content. Therefore, it can be taken over a long term. Moreover, because of being tasteless and odorless, nobiletin would not damage the unique taste of a food when added thereto. Therefore, it can be added to foods and taken.
Inventors:
Takao Sasaki
Application Number:
JP2006542437A
Publication Date:
April 16, 2014
Filing Date:
November 04, 2005
Export Citation:
Assignee:
Arkray Co., Ltd.
International Classes:
A61K31/353; A61K36/00; A61K36/75; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; C07D311/30
Domestic Patent References:
| JP2002080362A | 2002-03-19 | |||
| JP2000080035A | 2000-03-21 | |||
| JP2001240539A | 2001-09-04 | |||
| JP2002080362A | 2002-03-19 | |||
| JP2000247880A | 2000-09-12 |
Foreign References:
| WO2003037316A1 | 2003-05-08 |
Other References:
JPN7012000153; ＫＵＲＯＷＳＫＡ，Ｅ．Ｍ． ｅｔ ａｌ: 'Ｍｏｄｕｌａｔｉｏｎ ｏｆ ＨｅｐＧ２ ｃｅｌｌ ｎｅｔ ａｐｏｌｉｐｏｐｒｏｔｅｉｎ Ｂ ｓｅｃｒｅｔｉｏｎ ｂｙ ｔｈｅ ｃｉｔｒｕｓ ｐｏｌｙｍｅｔｈｏｘｙｆｌａｖｏｎｅ， ｔａｎｇｅｒｅｔｉｎ' Ｌｉｐｉｄｓ Ｖｏｌ．３９， Ｎｏ．２, 2004, ｐ．１４３-１５１
JPN6012019912; ＬＩＡＮＧ，Ｙ． ｅｔ ａｌ: 'Ｓｕｐｐｒｅｓｓｉｏｎ ｏｆ ｉｎｄｕｃｉｂｌｅ ｃｙｃｌｏｏｘｙｇｅｎａｓｅ ａｎｄ ｎｉｔｒｉｃ ｏｘｉｄｅ ｓｙｎｔｈａｓｅ ｔｈｒｏｕｇｈ ａｃｔｉｖａｔｉｏｎ ｏｆ ｐｅｒｏｘｉｓｏｍｅ ｐ' ＦＥＢＳ Ｌｅｔｔｅｒｓ Ｖｏｌ．４９６， Ｎｏ．１, 2001, ｐ．１２-１８
JPN6012019915; ＫＵＲＯＤＡ，Ｍ． ｅｔ ａｌ: 'Ｐｈｅｎｏｌｉｃｓ ｗｉｔｈ ＰＰＡＲ-gamma ｌｉｇａｎｄ-Ｂｉｎｄｉｎｇ ａｃｔｉｖｉｔｙ ｏｂｔａｉｎｅｄ ｆｒｏｍ ｌｉｃｏｒｉｃｅ （Ｇｌｙｃｙｒｒｈｉｚａ ｕｒａｌｅｎｓｉｓ Ｒｏｏｔｓ）' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．１３， Ｎｏ．２４, 2003, ｐ．４２６７-４２７２
JPN6012019916; ＭＡＥ，Ｔ． ｅｔ ａｌ: 'Ａ ｌｉｃｏｒｉｃｅ ｅｔｈａｎｏｌｉｃ ｅｘｔｒａｃｔ ｗｉｔｈ ｐｅｒｏｘｉｓｏｍｅ ｐｒｏｌｉｆｅｒａｔｏｒ-ａｃｔｉｖａｔｅｄ ｒｅｃｅｐｔｏｒ-gamma ｌｉｇａｎｄ-ｂｉｎｄｉｎｇ ａｃｔｉｖ' Ｊｏｕｒｎａｌ ｏｆ Ｎｕｔｒｉｔｉｏｎ Ｖｏｌ．１３３， Ｎｏ．１１, 2003, ｐ．３３６９-３３７７
JPN7012000153; ＫＵＲＯＷＳＫＡ，Ｅ．Ｍ． ｅｔ ａｌ: 'Ｍｏｄｕｌａｔｉｏｎ ｏｆ ＨｅｐＧ２ ｃｅｌｌ ｎｅｔ ａｐｏｌｉｐｏｐｒｏｔｅｉｎ Ｂ ｓｅｃｒｅｔｉｏｎ ｂｙ ｔｈｅ ｃｉｔｒｕｓ ｐｏｌｙｍｅｔｈｏｘｙｆｌａｖｏｎｅ， ｔａｎｇｅｒｅｔｉｎ' Ｌｉｐｉｄｓ Ｖｏｌ．３９， Ｎｏ．２, 2004, ｐ．１４３-１５１
JPN6012019909; 江口ら: 日本農芸化学会大会講演要旨集 , 2004, ｐ．６１
JPN6012019912; ＬＩＡＮＧ，Ｙ． ｅｔ ａｌ: 'Ｓｕｐｐｒｅｓｓｉｏｎ ｏｆ ｉｎｄｕｃｉｂｌｅ ｃｙｃｌｏｏｘｙｇｅｎａｓｅ ａｎｄ ｎｉｔｒｉｃ ｏｘｉｄｅ ｓｙｎｔｈａｓｅ ｔｈｒｏｕｇｈ ａｃｔｉｖａｔｉｏｎ ｏｆ ｐｅｒｏｘｉｓｏｍｅ ｐ' ＦＥＢＳ Ｌｅｔｔｅｒｓ Ｖｏｌ．４９６， Ｎｏ．１, 2001, ｐ．１２-１８
JPN6012019915; ＫＵＲＯＤＡ，Ｍ． ｅｔ ａｌ: 'Ｐｈｅｎｏｌｉｃｓ ｗｉｔｈ ＰＰＡＲ-gamma ｌｉｇａｎｄ-Ｂｉｎｄｉｎｇ ａｃｔｉｖｉｔｙ ｏｂｔａｉｎｅｄ ｆｒｏｍ ｌｉｃｏｒｉｃｅ （Ｇｌｙｃｙｒｒｈｉｚａ ｕｒａｌｅｎｓｉｓ Ｒｏｏｔｓ）' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．１３， Ｎｏ．２４, 2003, ｐ．４２６７-４２７２
JPN6012019916; ＭＡＥ，Ｔ． ｅｔ ａｌ: 'Ａ ｌｉｃｏｒｉｃｅ ｅｔｈａｎｏｌｉｃ ｅｘｔｒａｃｔ ｗｉｔｈ ｐｅｒｏｘｉｓｏｍｅ ｐｒｏｌｉｆｅｒａｔｏｒ-ａｃｔｉｖａｔｅｄ ｒｅｃｅｐｔｏｒ-gamma ｌｉｇａｎｄ-ｂｉｎｄｉｎｇ ａｃｔｉｖ' Ｊｏｕｒｎａｌ ｏｆ Ｎｕｔｒｉｔｉｏｎ Ｖｏｌ．１３３， Ｎｏ．１１, 2003, ｐ．３３６９-３３７７
JPN7012000153; ＫＵＲＯＷＳＫＡ，Ｅ．Ｍ． ｅｔ ａｌ: 'Ｍｏｄｕｌａｔｉｏｎ ｏｆ ＨｅｐＧ２ ｃｅｌｌ ｎｅｔ ａｐｏｌｉｐｏｐｒｏｔｅｉｎ Ｂ ｓｅｃｒｅｔｉｏｎ ｂｙ ｔｈｅ ｃｉｔｒｕｓ ｐｏｌｙｍｅｔｈｏｘｙｆｌａｖｏｎｅ， ｔａｎｇｅｒｅｔｉｎ' Ｌｉｐｉｄｓ Ｖｏｌ．３９， Ｎｏ．２, 2004, ｐ．１４３-１５１
JPN6012019909; 江口ら: 日本農芸化学会大会講演要旨集 , 2004, ｐ．６１
Attorney, Agent or Firm:
Ikeuchi, Sato & Partners