Title:
アルツハイマー病のためのバイオマーカー
Document Type and Number:
Japanese Patent JP5479379
Kind Code:
B2
Abstract:
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Alzheimer's disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as Alzheimer's or non-Alzheimer's dementia or normal. The biomarkers can be detected by SELDI mass spectrometry. In addition, the invention provides appropriate treatment interventions and methods for measuring response to treatment. Certain biomarkers of the invention may also be suitable for employment as radio-labeled ligands in non-invasive imaging techniques such as Positron Emission Tomography (PET).
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Inventors:
Hugh Alan Davis
James maguire
Anjah David Simonsen
Kai Brennau
Vladimir Podost
James maguire
Anjah David Simonsen
Kai Brennau
Vladimir Podost
Application Number:
JP2011012368A
Publication Date:
April 23, 2014
Filing Date:
January 24, 2011
Export Citation:
Assignee:
Vermilion Incorporated
International Classes:
G01N33/68; G01N27/62; G01N33/48; G01N33/50; G01N33/53; C12N
Foreign References:
| WO2004001421A2 |
Other References:
Han-Ling Yu et al.,Aberrant profiles of native and oxidized glycoproteins in Alzheimer plasma,PROTEOMICS,2003年 6月11日,Volume 3, Issue 11,2240-2248
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita