Title:
植物体中でのシアル酸の合成
Document Type and Number:
Japanese Patent JP5502328
Kind Code:
B2
Abstract:
A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.
Inventors:
Pakale, Thomas
Bardol, Murrier
Riu, Christoph
Gomor, Veronique
Faye, Lower
Le Rouge, Patrice
Akin, Stephanie
Vegina, Lewis-Philippe
Deuce, Marc-Andre
Bardol, Murrier
Riu, Christoph
Gomor, Veronique
Faye, Lower
Le Rouge, Patrice
Akin, Stephanie
Vegina, Lewis-Philippe
Deuce, Marc-Andre
Application Number:
JP2008553589A
Publication Date:
May 28, 2014
Filing Date:
February 09, 2007
Export Citation:
Assignee:
Medicago Inc.
Center National de la Cerche Scientific
Université du Reuen
Center National de la Cerche Scientific
Université du Reuen
International Classes:
C12N15/09; A01H5/00; A61K36/48; A61K36/81; A61K38/00; A61K39/395; C12N5/10; C12P19/28; C12P21/02
Domestic Patent References:
| JP2001136982A |
Foreign References:
| WO2004063370A1 | ||||
| WO2005090552A1 | ||||
| WO2003072783A1 |
Other References:
Nucleic Acids Res. 1985 Dec 20;13(24):8843-52.
Mol Microbiol. 2000 Mar;35(5):1120-34.
Biochem Biophys Res Commun Vol.339 No.4 Page.1184-1189 (2006.01.27)
Mol Microbiol. 2000 Mar;35(5):1120-34.
Biochem Biophys Res Commun Vol.339 No.4 Page.1184-1189 (2006.01.27)
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita