Title:
アンチセンスオリゴヌクレドチドによるSTAT3発現の調節
Document Type and Number:
Japanese Patent JP5507617
Kind Code:
B2
Abstract:
Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression and for promotion of apoptosis are provided. Methods for treatment of diseases, particularly inflammatory diseases and cancers, associated with overexpression or constitutive activation of STAT3 or insufficient apoptosis are also provided.
Inventors:
James G. Crow
Application Number:
JP2012129201A
Publication Date:
May 28, 2014
Filing Date:
June 06, 2012
Export Citation:
Assignee:
Isis Pharmaceuticals, Inc.
International Classes:
C12N15/09; A61K31/7088; C12N15/113; A61K31/711; A61K48/00; A61P19/02; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P43/00; C07H21/02; C07H21/04; C12Q1/02; A61K38/00
Domestic Patent References:
| JP2002541784A |
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Hiroko Ejiri
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Hiroko Ejiri