Title:
ヘパリン結合上皮細胞増殖因子様増殖因子に結合するモノクローナル抗体
Document Type and Number:
Japanese Patent JP5532401
Kind Code:
B2
Abstract:
Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.
Inventors:
Megada Eisuke
Ryo Iwamoto
Shingo Miyamoto
Kenya Shitara
Yukiko Furuya
Kazuyasu Nakamura
Kumiko Takahashi
Hiroshi Ando
Kazuhiro Masuda
Yuka Sasaki
Ryo Iwamoto
Shingo Miyamoto
Kenya Shitara
Yukiko Furuya
Kazuyasu Nakamura
Kumiko Takahashi
Hiroshi Ando
Kazuhiro Masuda
Yuka Sasaki
Application Number:
JP2009544756A
Publication Date:
June 25, 2014
Filing Date:
December 05, 2008
Export Citation:
Assignee:
Kyowa Hakko Kirin Co., Ltd.
International Classes:
C12N15/09; A61K39/395; A61P9/00; A61P9/10; A61P35/00; A61P43/00; C07K16/22; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Foreign References:
| WO2007142277A1 | 2007-12-13 |
Other References:
JPN6008066386; フナコシ総合カタログ２００５-２００６試薬編［抗体］ , 20051222, ｐ．４７４
JPN6008066388; ＭＩＹＡＭＯＴＯ， Ｓ． ｅｔ ａｌ．: '"Ｈｅｐａｒｉｎ-ｂｉｎｄｉｎｇ ｅｐｉｄｅｒｍａｌ ｇｒｏｗｔｈ ｆａｃｔｏｒ-ｌｉｋｅ ｇｒｏｗｔｈ ｆａｃｔｏｒ ａｓ ａ ｎｏｖｅｌ ｔａｒｇｅｔｉｎｇ ｍｏｌｅｃｕｌｅ ｆｏｒ ｃａｎｃｅｒ' ＣＡＮＣＥＲ ＳＣＩ． Ｖｏｌ．９７， Ｎｏ．５, 200605, ｐ．３４１-３４７
JPN6008066389; ＭＣＣＡＲＴＨＹ， Ｓ． Ａ． ｅｔ ａｌ．: '"Ｒａｐｉｄ ｉｎｄｕｃｔｉｏｎ ｏｆ ｈｅｐａｒｉｎ-ｂｉｎｄｉｎｇ ｅｐｉｄｅｒｍａｌ ｇｒｏｗｔｈ ｆａｃｔｏｒ／ｄｉｐｈｔｈｅｒｉａ ｔｏｘｉｎ ｒｅｃｅｐｔｏｒ ｅｘｐｒｅｓｓｉｏｎ ｂｙ' ＧＥＮＥＳ ＡＮＤ ＤＥＶＥＬＯＰＭＥＮＴ Ｖｏｌ．９, 1995, ｐ．１９５３-１９６４
JPN6008066390; ＹＯＴＳＵＭＯＴＯ， Ｆ． ｅｔ ａｌ．: '"Ｖａｌｉｄａｔｉｏｎ ｏｆ ＨＢ-ＥＧＦ ａｎｄ ａｍｐｈｉｒｅｇｕｌｉｎ ａｓ ｔａｒｇｅｔｓ ｆｏｒ ｈｕｍａｎ ｃａｎｃｅｒ ｔｈｅｒａｐｙ．"' ＢＩＯＣＨＥＭＩＣＡＬ ＡＮＤ ＢＩＯＰＨＹＳＩＣＡＬ ＲＥＳＥＡＲＣＨ ＣＯＭＭＵＮＩＣＡＴＩＯＮＳ Ｖｏｌ．３６５, 20071120, ｐ．５５５-５６１
JPN6008066388; ＭＩＹＡＭＯＴＯ， Ｓ． ｅｔ ａｌ．: '"Ｈｅｐａｒｉｎ-ｂｉｎｄｉｎｇ ｅｐｉｄｅｒｍａｌ ｇｒｏｗｔｈ ｆａｃｔｏｒ-ｌｉｋｅ ｇｒｏｗｔｈ ｆａｃｔｏｒ ａｓ ａ ｎｏｖｅｌ ｔａｒｇｅｔｉｎｇ ｍｏｌｅｃｕｌｅ ｆｏｒ ｃａｎｃｅｒ' ＣＡＮＣＥＲ ＳＣＩ． Ｖｏｌ．９７， Ｎｏ．５, 200605, ｐ．３４１-３４７
JPN6008066389; ＭＣＣＡＲＴＨＹ， Ｓ． Ａ． ｅｔ ａｌ．: '"Ｒａｐｉｄ ｉｎｄｕｃｔｉｏｎ ｏｆ ｈｅｐａｒｉｎ-ｂｉｎｄｉｎｇ ｅｐｉｄｅｒｍａｌ ｇｒｏｗｔｈ ｆａｃｔｏｒ／ｄｉｐｈｔｈｅｒｉａ ｔｏｘｉｎ ｒｅｃｅｐｔｏｒ ｅｘｐｒｅｓｓｉｏｎ ｂｙ' ＧＥＮＥＳ ＡＮＤ ＤＥＶＥＬＯＰＭＥＮＴ Ｖｏｌ．９, 1995, ｐ．１９５３-１９６４
JPN6008066390; ＹＯＴＳＵＭＯＴＯ， Ｆ． ｅｔ ａｌ．: '"Ｖａｌｉｄａｔｉｏｎ ｏｆ ＨＢ-ＥＧＦ ａｎｄ ａｍｐｈｉｒｅｇｕｌｉｎ ａｓ ｔａｒｇｅｔｓ ｆｏｒ ｈｕｍａｎ ｃａｎｃｅｒ ｔｈｅｒａｐｙ．"' ＢＩＯＣＨＥＭＩＣＡＬ ＡＮＤ ＢＩＯＰＨＹＳＩＣＡＬ ＲＥＳＥＡＲＣＨ ＣＯＭＭＵＮＩＣＡＴＩＯＮＳ Ｖｏｌ．３６５, 20071120, ｐ．５５５-５６１
Attorney, Agent or Firm:
Hironori Honda
Toshimitsu Ichikawa
Furudate Kutanko
Toshimitsu Ichikawa
Furudate Kutanko