Title:
ＮＯＴＣＨ結合剤およびアンタゴニストならびにその使用方法
Document Type and Number:
Japanese Patent JP5560270
Kind Code:
B2
Abstract:
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-hgand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-hgand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
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Inventors:
Gurnee. Austin El.
Hoy Timothy Charles
Tun Van Dale Khost Edward セイン
Sato Aaron Ken
Lieu ユアン Ching
ブルーンス Maureen Fitch
レウィッキ John Ey.
Hoy Timothy Charles
Tun Van Dale Khost Edward セイン
Sato Aaron Ken
Lieu ユアン Ching
ブルーンス Maureen Fitch
レウィッキ John Ey.
Application Number:
JP2011517416A
Publication Date:
July 23, 2014
Filing Date:
July 08, 2009
Export Citation:
Assignee:
On-コメッド Fame shoe tee カルズ In condominium lei テッド
International Classes:
C12N15/09; A61K39/395; A61P35/00; A61P43/00; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Attorney, Agent or Firm:
Spring water Original aim
Masao Haruna
Hirotaka Yamaguchi
Shun Osakabe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shin-ichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Osakabe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shin-ichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
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