Title:
ヌクレアーゼプロドラッグの酵素アクチベーターとしてのプリンヌクレオシドホスホリラーゼ
Document Type and Number:
Japanese Patent JP5567016
Kind Code:
B2
Abstract:
A process for inhibiting a mammalian cancerous cell or virally infected cell includes providing a Trichomonas vaginalis purine nucleoside phosphorylase enzyme or a tail mutant purine nucleoside phosphorylase enzyme in proximity to the mammalian cancerous cell or the virally infected cell and exposing the enzyme to a purine nucleoside phosphorylase enzyme cleavable substrate to yield a cytotoxic purine analog. The process includes introducing to the cell a vector containing the phosphorylase enzyme, or a DNA sequence coding for the same and delivering to the cell an effective amount of the substrate such as 9-(²-D-arabinofuranosyl)-2-fluoroadenine (F-araA).
Inventors:
William Bee Parker
Eric Jay Sosher
Eric Jay Sosher
Application Number:
JP2011523217A
Publication Date:
August 06, 2014
Filing Date:
August 17, 2009
Export Citation:
Assignee:
The U-B Research Research Foundation
Southern Research Institute
Southern Research Institute
International Classes:
A61K38/46; A61K31/7076; A61K35/12; A61K48/00; A61P35/00
Domestic Patent References:
| JP9502612A |
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro