ｐＨ感受性金属ナノ粒子およびその製造方法 - ポステック Academy * industry Foundation

Title:

ｐＨ感受性金属ナノ粒子およびその製造方法

Document Type and Number:

Japanese Patent JP5577329

Kind Code:

B2

Abstract:

The present invention relates to a pH sensitive particle, a method of preparation thereof, and a use thereof. More particularly, the invention provides a pH sensitive metal nanoparticle and its use for medical treatment utilizing cell necrosis during photothermal therapy. The pH sensitive metal nanoparticle based on this invention consists of a pH sensitive ligand compound whose charge changes depending on the pH of the metal nanoparticle. The particle can be collected in cells, such as cancer cells which present an abnormal pH environment. The pH sensitive metal nanoparticle based on this invention can induce cell death through a photothermal procedure after aggregation. Therefore, the invention enables medical treatment using cell necrosis for e.g. cancer treatment.

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Inventors:

Kim, Sun Lee
John, Sun ファ
Jon, ヒョギュン
Nahm, ジュ Taegu
One, ナ Yong

Application Number:

JP2011516156A

Publication Date:

August 20, 2014

Filing Date:

July 03, 2009

Export Citation:

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Assignee:

ポステック Academy * industry Foundation

International Classes:

C07C323/60; A61K33/24; A61K41/00; A61K47/20; A61K49/00; A61P35/00; B82Y5/00; B82Y40/00; C07F1/12

Attorney, Agent or Firm:

Tsugiharu Nishiura

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