Title:
ＨＩＶインテグラーゼ阻害剤
Document Type and Number:
Japanese Patent JP5600311
Kind Code:
B2
Abstract:
Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein X1, X2, Y, R1A, R1B, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Processes for making compounds of Formula I and intermediates thereof are also described.
Inventors:
An eye sack, Richard, See. Ey.
Thompson, Wayne, Jay.
Williams, Peter, Dee.
Soe, Di * Si
A ベンカ truck man, Shankar
エンブレー, a mark, W.
Fischer, トルステン, E.
Wai, John, S.
ドゥボスト, David, See.
A ball, Richard, Gee.
チョイ, Eric, Jay.
Pay, Tao
トライス, Sara, El.
Campbell, Neal
マデス, Matthew
Mali Gress, Peter, E.
Sheb Lynn, Michael
Son, ジグオ Jake
The Stein ヒューベル, Diedrich, Py.
A ストロット man, Neal, Ey.
Yim, gin ジュン
Thompson, Wayne, Jay.
Williams, Peter, Dee.
Soe, Di * Si
A ベンカ truck man, Shankar
エンブレー, a mark, W.
Fischer, トルステン, E.
Wai, John, S.
ドゥボスト, David, See.
A ball, Richard, Gee.
チョイ, Eric, Jay.
Pay, Tao
トライス, Sara, El.
Campbell, Neal
マデス, Matthew
Mali Gress, Peter, E.
Sheb Lynn, Michael
Son, ジグオ Jake
The Stein ヒューベル, Diedrich, Py.
A ストロット man, Neal, Ey.
Yim, gin ジュン
Application Number:
JP2011215915A
Publication Date:
October 01, 2014
Filing Date:
September 30, 2011
Export Citation:
Assignee:
Merck sharp and dome corporation Merck Sharp & Dohme Corp.
International Classes:
C07D487/04; C07D498/04; C07B61/00
Attorney, Agent or Firm:
Iwase Yoshiwa
Makoto Ono
Yoshinori Kanayama
Michiaki Tsubokura
Kazuteru Shigemori
Yasufumi Shiroyama
Kenji Ando
Makoto Ono
Yoshinori Kanayama
Michiaki Tsubokura
Kazuteru Shigemori
Yasufumi Shiroyama
Kenji Ando