Title:
ミトコンドリア由来の抗ガン化合物
Document Type and Number:
Japanese Patent JP5616798
Kind Code:
B2
Abstract:
This invention relates to anti-cancer compounds and to methods for treating or preventing cancer. In one aspect the invention concerns mitochondrially delivered pro-oxidant anti-cancer compounds that generate reactive oxygen species and induce apoptosis of cancerous cells. The delivery moiety can be a lipophilic cation and the pro-oxidant moiety can be a pro-oxidant vitamin E analogue, such as α-tocopheryl succinate, α-tocopheryl maleate, α-tocopheryl maleyl amide, or 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)-chroman-6-yloxyacetic acid (α-tocopheryloxyacetic acid).
Inventors:
スティーブン・ジョン・ラルフ
イリ・ネウジル
イリ・ネウジル
Application Number:
JP2010550000A
Publication Date:
October 29, 2014
Filing Date:
March 16, 2009
Export Citation:
Assignee:
スティーブン・ジョン・ラルフＳｔｅｐｈｅｎ Ｊｏｈｎ ＲＡＬＰＨ
イリ・ネウジルＪｉｒｉ ＮＥＵＺＩＬ
イリ・ネウジルＪｉｒｉ ＮＥＵＺＩＬ
International Classes:
C07F9/655; A61K31/665; A61K47/48; A61P35/00
Attorney, Agent or Firm:
Yasuo Tamura
Mutsumi Sameshima
Masahiro Nitta
Kure English 燦
Mutsumi Sameshima
Masahiro Nitta
Kure English 燦
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