Title:
高純度リポペプチド、リポペプチドミセルおよびこれらを調製するための処理
Document Type and Number:
Japanese Patent JP5631439
Kind Code:
B2
Abstract:
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of Streptomyces roseosporus. The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.
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Inventors:
ケルハー，トーマス ジェイ．
ライ，ジャン−ジ
デコーシー，ジョセフ ピー．
リンチ，ポール ディー．
ツェローニ，マウリツィオ
タリャーニ，アウロ エレ．
ライ，ジャン−ジ
デコーシー，ジョセフ ピー．
リンチ，ポール ディー．
ツェローニ，マウリツィオ
タリャーニ，アウロ エレ．
Application Number:
JP2013097659A
Publication Date:
November 26, 2014
Filing Date:
May 07, 2013
Export Citation:
Assignee:
キュービスト ファーマシューティカルズ， インコーポレイテッド
International Classes:
C07K1/18; A61K38/00; C12P21/02; A61K38/08; A61K38/10; A61K38/12; A61K45/00; A61K45/06; A61P29/00; A61P31/04; A61P31/10; C07K1/20; C07K1/34; C07K1/36; C07K5/097; C07K7/00; C07K7/08; C07K7/54; C12P17/16; C12R1/465; C07K
Attorney, Agent or Firm:
Iwase Yoshiwa
Makoto Ono
Yoshinori Kanayama
Michiaki Tsubokura
Kazuteru Shigemori
Yasufumi Shiroyama
Makoto Ono
Yoshinori Kanayama
Michiaki Tsubokura
Kazuteru Shigemori
Yasufumi Shiroyama