トピラマート（ＴＯＰＩＲＡＭＡＴＥ）の製造方法 - サイノファームタイワンリミテッド

Title:

トピラマート（ＴＯＰＩＲＡＭＡＴＥ）の製造方法

Document Type and Number:

Japanese Patent JP5643844

Kind Code:

B2

Abstract:

A process for the preparation of topiramate in an one pot reaction comprises the following steps: A) reacting 2,3:4,5-bis-O-{1-methylethylidene)-β-D-fructopyranose with sulfurylchloride in xylene in the presence of an organic or inorganic base to form 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfuryl chloride, B) adding a second organic solvent to the mixture obtained in step A) C) reacting the mixture obtained in step B) with ammonia to form topiramate.

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Inventors:

ワン、ルン−フ
ファン、チュン−テン

Application Number:

JP2012551954A

Publication Date:

December 17, 2014

Filing Date:

February 05, 2010

Export Citation:

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Assignee:

サイノファームタイワンリミテッド

International Classes:

C07H11/00

Attorney, Agent or Firm:

Mitsuru Kimura
Takanori Menju
Taiji Morikawa
Yasuhito Amemiya
Kei Sakurada
Mie Hideki

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