Title:
ミトコンドリア病の処置のための（ヘテロ）アリール−ｐ−キノン誘導体
Document Type and Number:
Japanese Patent JP5649454
Kind Code:
B2
Abstract:
Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Kearns-Sayre Syndrome (KSS), are disclosed, as well as compounds useful in the methods of the invention, such as 2-(3-hydroxy-3-methyl-butyl)-6-(het)aryl-p-quinone or as 2-(3-hydroxy-3-methylbutyl)-3-(het)aryl-p-quinone derivatives. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
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Inventors:
ヒンマン， アンドリュー ダブリュー．
ウェッソン， キエロン イー．
ウェッソン， キエロン イー．
Application Number:
JP2010542313A
Publication Date:
January 07, 2015
Filing Date:
January 06, 2009
Export Citation:
Assignee:
エジソン ファーマシューティカルズ， インコーポレイテッド
International Classes:
C07C50/28; A61K31/122; A61P3/00; A61P9/00; A61P21/02; A61P25/00; A61P25/02; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P43/00
Attorney, Agent or Firm:
Shusaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita