Title:
ＲＥＩＣ／Ｄｋｋ−３遺伝子の部分断片及び該断片を含むがん治療薬
Document Type and Number:
Japanese Patent JP5662534
Kind Code:
B2
Abstract:
This invention provides an inducer of apoptosis in cancer cells comprising a fragment of the REIC/Dkk-3 gene and a cancer therapeutic agent comprising the same. This invention also provides a polynucleotide fragment encoding the REIC/Dkk-3 protein (a) or (b), which encodes a polypeptide having apoptosis activity: (a) a polynucleotide encoding a polypeptide comprising an amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2; or (b) a polynucleotide encoding a polypeptide comprising an amino acid sequence derived from the amino acid sequence of amino acid 1 to any of amino acids 39 to 78 of the amino acid sequence of the REIC/Dkk-3 protein as shown in SEQ ID NO: 2 by substitution, deletion, or addition of 1 or several amino acids and having apoptosis activity.
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Inventors:
公文 裕巳
許 南浩
阪口 政清
那須 保友
アバルズア カベサス フェルナンド ギゲルモ
許 南浩
阪口 政清
那須 保友
アバルズア カベサス フェルナンド ギゲルモ
Application Number:
JP2013177942A
Publication Date:
January 28, 2015
Filing Date:
August 29, 2013
Export Citation:
Assignee:
公文 裕巳
許 南浩
阪口 政清
那須 保友
アバルズア カベサス フェルナンド ギゲルモ
許 南浩
阪口 政清
那須 保友
アバルズア カベサス フェルナンド ギゲルモ
International Classes:
A61K48/00; A61K38/00; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Yusuke Hiraki
Setsu Fujita
Natsuo Tanaka
Setsu Fujita
Natsuo Tanaka
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