Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
ペプチド誘導体及びその使用
Document Type and Number:
Japanese Patent JP5669765
Kind Code:
B2
Abstract:
A new peptide derivative is provided. The peptide derivative is represented by the following general formula (I), where polypeptide ExP is a polypeptide that contains completely or partially the amino acid sequence of exendin-4, and the -L-Z group represents a group represented by the following formula (II) that is bound to an amino acid side chain of, or the ±-amino group at the N-terminus of, the polypeptide ExP,

Inventors:
佐治 英郎
稲垣 暢也
木村 寛之
豊田 健太郎
平尾 佳
松田 洋和
Application Number:
JP2011554317A
Publication Date:
February 18, 2015
Filing Date:
October 07, 2011
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
国立大学法人京都大学
アークレイ株式会社
International Classes:
C07K14/605; A61K38/26; A61K51/00; G01T1/161
Other References:
JPN6013044210; RAUFMAN, J.P. et al.: '"Truncated glucagon-like peptide-1 interacts with exendin receptors on dispersed acini from guinea p' J. BIOL. CHEM. Vol.267, No.30, 19921025, P.21432-21437
JPN6013044212; GOKE, R. et al.: '"Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucago' J. BIOL. CHEM. Vol.268, No.26, 19930915, P.19650-19655
JPN6011061538; BLAKELY, B. et al.: '"Formulation and characterization of radio-opaque conjugated in situ gelling materials."' J. BIOMED. MATER. RES. B APPL. BIOMATER. Vol.93, No.1, 201004, P.9-17
JPN6011061529; LEUNG, K.: '"3-(4-Hydroxy-3-[125I]iodophenyl)propionate-exendin(9-39)."' Molecular Imaging and Contrast Agent Database (MICAD) [Internet] , 20100406, Bookshelf ID: NBK44818, PMID: 20642016, NCBI
JPN6011061530; MUKAI, E. et al.: '"GLP-1 receptor antagonist as a potential probe for pancreatic beta-cell imaging."' BIOCHEM. BIOPHYS. RES. COMMUN. Vol.389, No.3, 20091120, P.523-526
JPN6011061531; WILD, D. et al.: '"Exendin-4-based radiopharmaceuticals for glucagonlike peptide-1 receptor PET/CT and SPECT/CT."' J. NUCL. MED. Vol.51, No.7, 201007, P.1059-1067
JPN6011061533; CHENG, K.T.: '"[18F]FB-NH-mini-PEG-E{E[c(RGDyK)]2}2."' Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. , 20080220, Bookshelf ID: NBK23235, PMID: 20641437, NCBI
JPN6011061534; LIU, Z. et al.: '"(68)Ga-labeled cyclic RGD dimers with Gly3 and PEG4 linkers: promising agents for tumor integrin al' EUR. J. NUCL. MED. MOL. IMAGING Vol.36, No.6, 200906, P.947-957
JPN6011061536; MELENDEZ-ALAFORT, L. et al.: '"Detection of sites of infection in mice using 99mTc-labeled PN(2)S-PEG conjugated to UBI and 99mTc-' NUCL. MED. BIOL. Vol.36, No.1, 200901, P.57-64
JPN6011061529; LEUNG, K.: '"3-(4-Hydroxy-3-[125I]iodophenyl)propionate-exendin(9-39)."' Molecular Imaging and Contrast Agent Database (MICAD) [Internet] , 20100406, Bookshelf ID: NBK44818, PMID: 20642016, NCBI
JPN6011061530; MUKAI, E. et al.: '"GLP-1 receptor antagonist as a potential probe for pancreatic beta-cell imaging."' BIOCHEM. BIOPHYS. RES. COMMUN. Vol.389, No.3, 20091120, P.523-526
JPN6011061531; WILD, D. et al.: '"Exendin-4-based radiopharmaceuticals for glucagonlike peptide-1 receptor PET/CT and SPECT/CT."' J. NUCL. MED. Vol.51, No.7, 201007, P.1059-1067
JPN6011061533; CHENG, K.T.: '"[18F]FB-NH-mini-PEG-E{E[c(RGDyK)]2}2."' Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. , 20080220, Bookshelf ID: NBK23235, PMID: 20641437, NCBI
JPN6011061534; LIU, Z. et al.: '"(68)Ga-labeled cyclic RGD dimers with Gly3 and PEG4 linkers: promising agents for tumor integrin al' EUR. J. NUCL. MED. MOL. IMAGING Vol.36, No.6, 200906, P.947-957
JPN6011061536; MELENDEZ-ALAFORT, L. et al.: '"Detection of sites of infection in mice using 99mTc-labeled PN(2)S-PEG conjugated to UBI and 99mTc-' NUCL. MED. BIOL. Vol.36, No.1, 200901, P.57-64
JPN6013044210; RAUFMAN, J.P. et al.: '"Truncated glucagon-like peptide-1 interacts with exendin receptors on dispersed acini from guinea p' J. BIOL. CHEM. Vol.267, No.30, 19921025, P.21432-21437
JPN6013044212; GOKE, R. et al.: '"Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucago' J. BIOL. CHEM. Vol.268, No.26, 19930915, P.19650-19655
JPN6011061538; BLAKELY, B. et al.: '"Formulation and characterization of radio-opaque conjugated in situ gelling materials."' J. BIOMED. MATER. RES. B APPL. BIOMATER. Vol.93, No.1, 201004, P.9-17
JPN6014051120; 向英里、外11名: '「GLP-1受容体をターゲットにした分子プローブによる膵島の非侵襲的イメージング」' 糖尿病 Vol.52, No.Supplement 1, 20090425, P.S-329
Attorney, Agent or Firm:
Patent business corporation Ikeuchi and Sato and partners