Title:
各種疾患の治療に最適なＮ，Ｎジアミノジフェニールスルフォン酸塩の医薬用溶融物
Document Type and Number:
Japanese Patent JP5671010
Kind Code:
B2
Abstract:
The present invention aims to demonstrate that a soluble pharmaceutical formulation can be prepared of N,N'-Diaminodiphenyl sulfone which is useful in the development of an ideal drug for use against cerebral infarction, epilepsy, traumatic spinal cord injury, cranio-encephalic trauma, leprosy, Pneumocystis carinii infections and any condition which requires rapid and complete absorption of the compound. A s a representative example of this application, the dissolution of N,N'-Diamino-diphenyl sulfone was evaluated as a neuroprotector in a model of acute cerebral infarction in rats. In this study, N,N'-Diamino-diphenyl sulfone showed significant prevention of brain damage, without presenting adverse effects in animals. It is also shown that the soluble pharmaceutical formulations prepared in this manner produce peak blood levels 30 minutes from oral administration and immediately via the intravenous route.
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Inventors:
アルタグラシア マルティネス，マリナ
リオス カスタネダ，ルイス カミロ
クラブソブ ヒニチェ，ハイメ
ダイス ルイス，マリア デ ロス アンゲレス アラセリ
リオス カスタネダ，ルイス カミロ
クラブソブ ヒニチェ，ハイメ
ダイス ルイス，マリア デ ロス アンゲレス アラセリ
Application Number:
JP2012508413A
Publication Date:
February 18, 2015
Filing Date:
October 05, 2009
Export Citation:
Assignee:
ウニベルシダド アウトノマ メトロポリタナ
International Classes:
A61K31/145; A61K9/08; A61K47/10; A61K47/22; A61P7/04; A61P9/10; A61P31/08
Attorney, Agent or Firm:
Haruo Hamada
West entrance 克
Teiji Akatsu
Ryoko Saito
West entrance 克
Teiji Akatsu
Ryoko Saito