Title:
ＨＳＰ９０活性を調節するイミダゾール化合物
Document Type and Number:
Japanese Patent JP5683787
Kind Code:
B2
Abstract:
Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell Variable R5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein.
Inventors:
イン ウェイウェン
ドゥ チェンジャン
フォーレイ ケヴィン
ドゥ チェンジャン
フォーレイ ケヴィン
Application Number:
JP2008527009A
Publication Date:
March 11, 2015
Filing Date:
August 10, 2006
Export Citation:
Assignee:
シンタ ファーマシューティカルズ コーポレーション
International Classes:
C07D233/64; C07D233/70; C07D401/04; C07D403/04; C07D405/04; C07D417/04; C07D473/34
Attorney, Agent or Firm:
Spring water Original aim
Shun Osakabe
Koichi Niimi
Tomohiko Kobayashi
Shin-ichi Watanabe
Ryuichi Inoue
Shun Osakabe
Koichi Niimi
Tomohiko Kobayashi
Shin-ichi Watanabe
Ryuichi Inoue